ArticleInfection and immunity2003
The luxS gene of Streptococcus pyogenes regulates expression of genes that affect internalization by epithelial cells.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
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- Effects of artificial honey and epigallocatechin-3-gallate on streptococcus pyogenes.BMC microbiology · 2022Article
- The Role of SprIR Quorum Sensing System in the Regulation ofMicroorganisms · 2021Article
- Revisiting the inoculum effect for Streptococcus pyogenes with a hollow fibre infection model.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Deciphering Streptococcal Biofilms.Microorganisms · 2020Review
- Impact of Citral and Phloretin, Alone and in Combination, on Major Virulence Traits ofMolecules (Basel, Switzerland) · 2019Article
- Current Understanding of Group A Streptococcal Biofilms.Current drug targets · 2019Review
- Inhibitory role of acyl homoserine lactones in hemolytic activity and viability of Streptococcus pyogenes M6 S165.Scientific reports · 2017Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Cysteine-Mediated Gene Expression and Characterization of the CmbR Regulon inFrontiers in microbiology · 2016Article
- Clinical implications and characterization of Group A Streptoccoccus infections in adults with cystic fibrosis.BMC pulmonary medicine · 2015Article
- The interaction between Streptococcus spp. and Veillonella tobetsuensis in the early stages of oral biofilm formation.Journal of bacteriology · 2015Article
- covR Mediated Antibiofilm Activity of 3-Furancarboxaldehyde Increases the Virulence of Group A Streptococcus.PloS one · 2015Article
- Streptococcus pyogenes biofilms-formation, biology, and clinical relevance.Frontiers in cellular and infection microbiology · 2015Review
- Quorum sensing in group A Streptococcus.Frontiers in cellular and infection microbiology · 2014Review
- Heterologous expression of sahH reveals that biofilm formation is autoinducer-2-independent in Streptococcus sanguinis but is associated with an intact activated methionine cycle.The Journal of biological chemistry · 2012Article
- Disrupting the luxS quorum sensing gene does not significantly affect Bacillus anthracis virulence in mice or guinea pigs.Virulence · 2012Article
- LsrR-mediated quorum sensing controls invasiveness of Salmonella typhimurium by regulating SPI-1 and flagella genes.PloS one · 2012Article
- Different aspects of bacterial communication signals.World journal of microbiology & biotechnology · 2011Article
- Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism.Molecular microbiology · 2011Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gram-positive pathogen Streptococcus pyogenes was recently reported to possess a homologue of the luxS gene that is responsible for the production of autoinducer 2, which participates in quorum sensing of both gram-positive and gram-negative bacteria. To test the effect of LuxS on streptococcal internalization, a LuxS mutant was constructed in strain SP268, an invasive M3 serotype. Functional analysis of the mutant revealed that it was internalized by HEp-2 cells with higher efficiency than the wild type (wt). Several genes, including hasA (hyaluronic acid synthesis), speB (streptococcal pyrogenic exotoxin B), and csrR (capsule synthesis regulator), a part of a two-component regulatory system, are known to affect the internalization of strain SP268 (J. Jadoun, O. Eyal, and S. Sela, Infect. Immun. 70:462-469, 2002). Therefore, the expression of these genes in the mutant and in the wt was examined. LuxS mutation significantly reduced the mRNA level of speB and increased the mRNA level of emm3. No substantial effect was observed on transcription of hasA and csrR. Yet less hyaluronic acid capsule was expressed in the mutant. Further analysis revealed that luxS is under the regulation of the two-component global regulator CsrR. Our results indicate that LuxS activity in strain SP268 plays an important role in the expression of virulence factors associated with epithelial cell internalization.
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