ArticleInfection and immunity2003
The global regulator ArcA modulates expression of virulence factors in Vibrio cholerae.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 80 citations in OpenAlex.
- Overview of functionally characterized two-component regulatory systems in Vibrio parahaemolyticus.Archives of microbiology · 2026Review
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- Genomic evidence of two-staged transmission of the early seventh cholera pandemic.Nature communications · 2024Article
- Non-O1/Non-O139Microorganisms · 2024Review
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- ArcB orchestrates the quorum-sensing system to regulate type III secretion system 1 inGut microbes · 2023Article
- The Rvv two-component regulatory system regulates biofilm formation and colonization in Vibrio cholerae.PLoS pathogens · 2023Article
- The ArcAB Two-Component System: Function in Metabolism, Redox Control, and Infection.Microbiology and molecular biology reviews : MMBR · 2022Review
- Vibrio cholerae senses human enteric α-defensin 5 through a CarSR two-component system to promote bacterial pathogenicity.Communications biology · 2022Article
- Vibrio cholerae requires oxidative respiration through the bd-I and cbb3 oxidases for intestinal proliferation.PLoS pathogens · 2022Article
- Thiol-based functional mimicry of phosphorylation of the two-component system response regulator ArcA promotes pathogenesis in enteric pathogens.Cell reports · 2021Article
- The effect of ArcA on the growth, motility, biofilm formation, and virulence of Plesiomonas shigelloides.BMC microbiology · 2021Article
- RegAB Homolog of Burkholderia pseudomallei is the Master Regulator of Redox Control and involved in Virulence.PLoS pathogens · 2021Article
- Pathogenicity and virulence regulation ofVirulence · 2020Review
- On or Off: Life-Changing Decisions Made byInfectious microbes & diseases · 2020Review
- An ArcA-Modulated Small RNA in PathogenicFrontiers in microbiology · 2020Article
- Virulence Regulation and Innate Host Response in the Pathogenicity ofFrontiers in cellular and infection microbiology · 2020Review
- Article
- Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview.Frontiers in microbiology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Vibrio cholerae arcA mutant was constructed and used to examine the role of the global anaerobiosis response regulator ArcA in the expression of virulence factors in this important human pathogen. In V. cholerae, expression of the major virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) is regulated by the transcriptional activator ToxT. toxT expression, in turn, is controlled by the transmembrane DNA binding proteins ToxR and TcpP. In the V. cholerae arcA mutant, although ToxR and TcpP were unaffected, Northern blot and reverse transcription-PCR analyses indicated that the expression of toxT was significantly decreased with concomitant reduction in the expression of CT and TCP. CT and TCP expression was completely restored in the V. cholerae arcA mutant strain by expressing a cloned toxT gene in the mutant. These results suggest that ArcA functions as a positive regulator of toxT expression under both aerobic and anaerobic conditions, although as expected, the effect was more pronounced during anaerobic growth. This was reflected in a reduction of virulence of the V. cholerae arcA mutant strain in the infant mouse cholera model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.