ArticleInfection and immunity2003
CadC is the preferential target of a convergent evolution driving enteroinvasive Escherichia coli toward a lysine decarboxylase-defective phenotype.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Molecular Prevalence of Diarrheal Pathogens in Children with Acute Diarrhea in Southeastern Gabon.The American journal of tropical medicine and hygiene · 2023Article
- ShigaPass: anMicrobial genomics · 2023Article
- Pathogenicity assessment of Shiga toxin-producingFrontiers in microbiology · 2023Article
- The emergence of the tetrathionate reductase operon in the Escherichia coli/Shigella pan-genome.MicrobiologyOpen · 2022Article
- How microbiological tests reflect bacterial pathogenesis and host adaptation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- Acid Evolution of Escherichia coli K-12 Eliminates Amino Acid Decarboxylases and Reregulates Catabolism.Applied and environmental microbiology · 2017Article
- Article
- The Intriguing Evolutionary Journey of EnteroinvasiveFrontiers in microbiology · 2017Review
- Investigating the Relatedness of Enteroinvasive Escherichia coli to Other E. coli and Shigella Isolates by Using Comparative Genomics.Infection and immunity · 2016Article
- Article
- Recent advances in understanding enteric pathogenic Escherichia coli.Clinical microbiology reviews · 2013Review
- Antivirulence genes: insights into pathogen evolution through gene loss.Infection and immunity · 2012Review
- CadC has a global translational effect during acid adaptation in Salmonella enterica serovar Typhimurium.Journal of bacteriology · 2007Article
- Plasticity of the P junc promoter of ISEc11, a new insertion sequence of the IS1111 family.Journal of bacteriology · 2006Article
- Pathoadaptive mutation that mediates adherence of shiga toxin-producing Escherichia coli O111.Infection and immunity · 2005Article
- Pathogenic Escherichia coli.Nature reviews. Microbiology · 2004Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enteroinvasive E. coli (EIEC), like Shigella, is the etiological agent of bacillary dysentery, a particularly severe syndrome in children in developing countries. All EIEC strains share with Shigella the inability to synthesize lysine decarboxylase (the LDC phenotype). The lack of this function is considered a pathoadaptive mutation whose emergence was necessary to obtain the full expression of invasiveness. Cadaverine, the product of lysine decarboxylation, is a small polyamine which interferes mainly with the inflammatory process induced by dysenteric bacteria. Genes coding for lysine decarboxylase and its transporter constitute a single operon (cadBA) and are expressed at low pH under the positive control of CadC. This regulator is an inner membrane protein that is able to sense pH variation and to respond by transcriptionally activating the cadBA genes. In this study we show that, unlike in Shigella, mutations affecting the cad locus in the EIEC strains we have analyzed are not followed by a novel gene arrangement and that the LCD(-) phenotype is dependent mainly on inactivation of the cadC gene. Introduction of a functional CadC restores cadaverine expression in all EIEC strains harboring either an IS2 element or a defective cadC promoter. Comparative analysis between the cad regions of S. flexneri and EIEC suggests that the LDC(-) phenotype has been attained by different strategies within the E. coli species.
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