ArticleBMC cancer2003
Tamoxifen stimulates arachidonic acid release from rat liver cells by an estrogen receptor-independent, non-genomic mechanism.
Article in BMC cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cell survival signalling through PPARδ and arachidonic acid metabolites in neuroblastoma.PloS one · 2013Article
- beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.The Journal of clinical investigation · 2009Article
- Breast cancer patients with estrogen receptor-negative/progesterone receptor-positive tumors: being younger and getting less benefit from adjuvant tamoxifen treatment.Journal of cancer research and clinical oncology · 2008Article
- Cyclooxygenase expression is not required for release of arachidonic acid from cells by some nonsteroidal anti-inflammatory drugs and cancer preventive agents.BMC pharmacology · 2006Article
- Tetrandrine and thapsigargin release arachidonic acid from cells in culture and stimulate prostacyclin production in rat liver cells, but may do so by different pathways.BMC pharmacology · 2005Article
- Article
- Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells.BMC pharmacology · 2004Article
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Authors and funding
1 author.
Funding
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Abstract
backgroundTamoxifen is widely prescribed for the treatment of breast cancer. Its success has been attributed to the modulation of the estrogen receptor. I have previously proposed that the release of arachidonic acid from cells may also mediate cancer prevention.
methodsRat liver cells were radiolabelled with arachidonic acid. The release of [3H] arachidonic acid after various times of incubation of the cells with tamoxifen was measured.
resultsTamoxifen, at micromolar concentrations, stimulates arachidonic acid release. The stimulation is rapid and is not affected by pre-incubation of the cells with actinomycin or the estrogen antagonist ICI-182,780.
conclusionsThe stimulation of AA release by tamoxifen is not mediated by estrogen receptor occupancy and is non-genomic.
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