ArticleThe Journal of cell biology1992
Maternal effect mutations of the sponge locus affect actin cytoskeletal rearrangements in Drosophila melanogaster embryos.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- Planer-polarized junction association of the RacGEF ELMO-Sponge contributes to planar polarity and germband extension in Drosophila embryos.Science China. Life sciences · 2025Article
- Maternal Spargel/dPGC-1 is critical for embryonic development and influences chorion gene amplification via Cyclin E activity.Developmental biology · 2024Article
- Global coupling of R-loop dynamics with RNA polymerase II modulates gene expression and early development of Drosophila.Nucleic acids research · 2024Article
- Centrosome-organized plasma membrane infoldings linked to growth of a cortical actin domain.The Journal of cell biology · 2024Article
- Article
- Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.The Journal of cell biology · 2024Article
- Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development.Results and problems in cell differentiation · 2024Review
- Astral microtubule cross-linking safeguards uniform nuclear distribution in the Drosophila syncytium.The Journal of cell biology · 2022Article
- Dia- and Rok-dependent enrichment of capping proteins in a cortical region.Journal of cell science · 2021Article
- Par-1 controls the composition and growth of cortical actin caps duringThe Journal of cell biology · 2019Article
- The Crk adapter protein is essential forMolecular biology of the cell · 2019Article
- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
- Article
- Posterior localization of ApVas1 positions the preformed germ plasm in the sexual oviparous pea aphid Acyrthosiphon pisum.EvoDevo · 2014Article
- Article
- Asymmetric Mbc, active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila.Development (Cambridge, England) · 2011Article
- The DOCK protein sponge binds to ELMO and functions in Drosophila embryonic CNS development.PloS one · 2011Article
- Rho-guanine nucleotide exchange factors during development: Force is nothing without control.Small GTPases · 2010Article
- Cortical actin dynamics facilitate early-stage centrosome separation.Current biology : CB · 2010Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the syncytial blastoderm stage of Drosophila embryogenesis, dome-shaped actin "caps" are observed above the interphase nuclei. During mitosis, this actin rearranges to participate in the formation of pseudocleavage furrows, transient membranous invaginations between dividing nuclei. Embryos laid by homozygous sponge mothers lack these characteristic actin structures, but retain other actin associated structures and processes. Our results indicate that the sponge product is specifically required for the formation of actin caps and metaphase furrows. The specificity of the sponge phenotype permits dissection of both the process of actin cap formation and the functions of actin caps and metaphase furrows. Our data demonstrate that the distribution of actin binding protein 13D2 is unaffected in sponge embryos and suggest that 13D2 is upstream of actin in cortical cap assembly. Although actin caps and metaphase furrows have been implicated in maintaining the fidelity of nuclear division and the positions of nuclei within the cortex, our observations indicate that these structures are dispensible during the early syncytial blastoderm cell cycles. A later requirement for actin metaphase furrows in preventing the nucleation of mitotic spindles between inappropriate centrosomes is observed. Furthermore, the formation of actin caps and metaphase furrows is not a prerequisite for the formation of the hexagonal array of actin instrumental in the conversion of the syncytial embryo into a cellular blastoderm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.