ArticleThe Journal of cell biology1992
Assembly and localization of the U1-specific snRNP C protein in the amphibian oocyte.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Biallelic variants in SNUPN cause a limb girdle muscular dystrophy with myofibrillar-like features.Brain : a journal of neurology · 2024Article
- Imaging the dynamics of transcription loops in living chromosomes.Chromosoma · 2018Article
- Article
- prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast.Nature structural & molecular biology · 2007Article
- Localized co-transcriptional recruitment of the multifunctional RNA-binding protein CELF1 by lampbrush chromosome transcription units.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- Review
- Subnuclear localization and Cajal body targeting of transcription elongation factor TFIIS in amphibian oocytes.Molecular biology of the cell · 2003Article
- Nucleocytoplasmic distribution of human RNA-editing enzyme ADAR1 is modulated by double-stranded RNA-binding domains, a leucine-rich export signal, and a putative dimerization domain.Molecular biology of the cell · 2002Article
- Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002Review
- The human but not the Xenopus RNA-editing enzyme ADAR1 has an atypical nuclear localization signal and displays the characteristics of a shuttling protein.Molecular biology of the cell · 2001Article
- An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins.The Journal of cell biology · 2000Article
- Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes.Molecular biology of the cell · 1999Article
- The RNA-editing enzyme ADAR1 is localized to the nascent ribonucleoprotein matrix on Xenopus lampbrush chromosomes but specifically associates with an atypical loop.The Journal of cell biology · 1999Article
- Xlrbpa, a double-stranded RNA-binding protein associated with ribosomes and heterogeneous nuclear RNPs.The Journal of cell biology · 1997Article
- The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain.Molecular and cellular biology · 1994Article
- Nuclear transport of U1 snRNP in somatic cells: differences in signal requirement compared with Xenopus laevis oocytes.The Journal of cell biology · 1994Article
- m3G cap hypermethylation of U1 small nuclear ribonucleoprotein (snRNP) in vitro: evidence that the U1 small nuclear RNA-(guanosine-N2)-methyltransferase is a non-snRNP cytoplasmic protein that requires a binding site on the Sm core domain.Molecular and cellular biology · 1994Article
- Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors.The Journal of cell biology · 1994Article
- A 69-kD protein that associates reversibly with the Sm core domain of several spliceosomal snRNP species.The Journal of cell biology · 1994Article
- A pre-export U1 snRNP in Xenopus laevis oocyte nuclei.Nucleic acids research · 1993Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To study the intranuclear localization of the U1-specific snRNP C protein and its assembly into U1 snRNPs, we injected transcripts encoding a myc-tagged C protein into amphibian oocytes. The distribution of protein translated from the injected RNA was essentially the same in continuous and pulse-label experiments. In both cases the C protein localized within the germinal vesicle in those structures known to contain U1 snRNPs, namely the lampbrush chromosome loops and hundreds of extrachromosomal granules called snurposomes. Oocytes were also injected with an antisense oligodeoxynucleotide that caused truncation of U1 snRNA at the 5' end. In these oocytes, myc-tagged C protein localized normally in the germinal vesicle and could be immunoprecipitated together with truncated U1 snRNA. These experiments suggest that the C protein can enter the germinal vesicle on its own and there associate with previously assembled U1 snRNPs. In transfected tissue culture cells, the myc-tagged C protein localized within the nucleus in a speckled pattern similar to that of endogenous U1 snRNPs.
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