ArticleThe Biochemical journal1992
Protein kinase C phosphorylation of cardiac troponin T decreases Ca(2+)-dependent actomyosin MgATPase activity and troponin T binding to tropomyosin-F-actin complex.
Article in The Biochemical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- Considering impact of age and sex on cardiac cytoskeletal components.American journal of physiology. Heart and circulatory physiology · 2024Review
- TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.Gene · 2016Review
- FRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation.Archives of biochemistry and biophysics · 2014Article
- Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation.Basic research in cardiology · 2014Article
- Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A.Journal of muscle research and cell motility · 2012Article
- Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart-detrimental or beneficial?Biophysical reviews · 2011Review
- Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice.Journal of molecular and cellular cardiology · 2010Article
- Dephosphorylation specificities of protein phosphatase for cardiac troponin I, troponin T, and sites within troponin T.International journal of biological sciences · 2006Article
- Thin filament remodeling in failing myocardium.Heart failure reviews · 2005Review
- Troponin T: genetics, properties and function.Journal of muscle research and cell motility · 1998Review
- Expression and regulation of mutant forms of cardiac TnI in a reconstituted actomyosin system: role of kinase dependent phosphorylation.Molecular and cellular biochemistry · 1997Article
- Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy.The Journal of clinical investigation · 1996Article
- Myofibrillar Ca2+ sensitivity of cardiomyopathic hamster hearts.Pflugers Archiv : European journal of physiology · 1995Article
- Signalling by protein kinase C isoforms in the heart.Molecular and cellular biochemistryReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Effects of phosphorylation of bovine cardiac troponin T (TnT) by protein kinase C on the Ca(2+)-stimulated MgATPase activity of reconstituted actomyosin complex and the binding of TnT to tropomyosin(Tm)-F-actin were investigated. The Ca(2+)-stimulated MgATPase of actomyosin containing phosphorylated TnT (1.8 mol of P/mol), compared with that containing unphosphorylated TnT, was decreased by up to 48%. Phosphorylation of TnT also decreased (up to 48%) its maximum binding to Tm-F-actin, which was accompanied by a decrease (up to 3.5-fold) in its apparent binding affinity. The findings indicate that the effects of phosphorylated TnT in decreasing actomyosin MgATPase might be secondary to its decreased interactions with the other components of the thin filament, representing a new mechanism underlying the negative inotropic responses of various cardiac preparations to protein kinase C-activating phorbol esters.
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