ArticleProceedings of the National Academy of Sciences of the United States of America1992
Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 160 citations in OpenAlex.
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- SFRP2 modulates functional phenotype transition and energy metabolism of macrophages during diabetic wound healing.Frontiers in immunology · 2024Article
- The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.International journal of molecular sciences · 2022Review
- Hyperosmolality in CHO cell culture: effects on the proteome.Applied microbiology and biotechnology · 2022Article
- The Multifaceted Roles of Proline in Cell Behavior.Frontiers in cell and developmental biology · 2021Review
- Characterization and functional analysis of Krtap11-1 during hair follicle development in Angora rabbits (Oryctolagus cuniculus).Genes & genomics · 2020Article
- Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes.Scientific reports · 2020Article
- Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.Frontiers in genetics · 2016Article
- Ancient origin of the gene encoding involucrin, a precursor of the cross-linked envelope of epidermis and related epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Functional studies of a novel oncogene TGM3 in human esophageal squamous cell carcinoma.World journal of gastroenterology · 2006Article
- DBC1 re-expression alters the expression of multiple components of the plasminogen pathway.Oncogene · 2006Article
- Regulatory role for Krüppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis.The Journal of investigative dermatology · 2006Article
- E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes.Oncogene · 2000Article
- Induction of tissue transglutaminase by dexamethasone: its correlation to receptor number and transglutaminase-mediated cell death in a series of malignant hamster fibrosarcomas.The Biochemical journal · 1998Article
- Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation.Molecular and cellular biology · 1996Article
- Identification of two cDNA clones encoding small proline-rich proteins expressed in sheep ruminal epithelium.The Biochemical journal · 1996Article
- A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product.Nucleic acids research · 1996Article
- Altered distribution of keratinization markers in epidermolytic hyperkeratosis.Archives of dermatological research · 1995Article
- Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.The Journal of cell biology · 1994Article
- Overexpression of human loricrin in transgenic mice produces a normal phenotype.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
In this study, we have characterized the cDNA clone SQ37 that was isolated previously from a rabbit squamous cell library. The gene encodes a 14-kDa protein that appears to function as a component of the cross-linked envelope in squamous differentiating cells. The protein, which has been named cornifin, has a high content of proline (31%), glutamine (20%), and cysteine (11%) and contains 13 repeats of an octapeptide (consensus sequence, EPCQPKVP) at its C terminus. SQ37 mRNA and protein are induced during squamous differentiation of rabbit tracheal (RbTE) cells and human epidermal keratinocytes. This induction is repressed by retinoids. Immunohistochemical studies reveal SQ37 immunoreactivity in fragmented cross-linked envelopes from squamous-differentiated RbTE cells and in the suprabasal layers of the epidermis. In situ hybridization analysis showed that the presence of SQ37 mRNA is restricted to the suprabasal layers. Treatment of RbTE cells with a Ca2+ ionophore induces cross-linking of the SQ37 protein into higher molecular weight complexes. This cross-linking reaction appears to be mediated by transglutaminase type I. Our observations suggest that the protein encoded by SQ37 participates in the assembly of the cross-linked envelope.
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