ArticleProceedings of the National Academy of Sciences of the United States of America1992
Induction of the neural cell adhesion molecule and neuronal aggregation by osteogenic protein 1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 46 citations in OpenAlex.
- The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation.Developmental neurobiology · 2012Review
- Antagonists of alcohol inhibition of cell adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer element.The Journal of cell biology · 1997Article
- Alcohol inhibits cell-cell adhesion mediated by human L1.The Journal of cell biology · 1996Article
- Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.British journal of cancer · 1996Article
- The neural cell adhesion molecule (N-CAM) inhibits proliferation in primary cultures of rat astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Detection of two transforming growth factor-beta-related morphogens, bone morphogenetic proteins-4 and -5, in RNA of multiple sclerosis and Creutzfeldt-Jakob disease lesions.Acta neuropathologica · 1995Article
- Hyaluronic acid and hyaluronic acid-binding proteins in brain extracellular matrix.Anatomy and embryology · 1993Review
- Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The neural cell adhesion molecule (N-CAM) plays a fundamental role in nervous system development and regeneration, yet the regulation of the expression of N-CAM in different brain regions has remained poorly understood. Osteogenic protein 1 (OP-1) is a member of the transforming growth factor beta superfamily that is expressed in the nervous system. Treatment of the neuroblastoma-glioma hybrid cell line NG108-15 for 1-4 days with recombinant human OP-1 (hOP-1) induced alterations in cell shape, formation of epithelioid sheets, and aggregation of cells into multilayered clusters. Immunofluorescence studies and Western blots demonstrated a striking differential induction of the three N-CAM isoforms in hOP-1-treated cells. hOP-1 caused a 6-fold up-regulation of the 140-kDa N-CAM, the isoform showing the highest constitutive expression, and a 29-fold up-regulation of the 180-kDa isoform. The 120-kDa isoform was not detected in control NG108-15 cells but was readily identified in hOP-1-treated cells. Incubation of NG108-15 cells with an antisense N-CAM oligonucleotide reduced the induction of N-CAM by hOP-1 and decreased the formation of multilayered cell aggregates. Anti-N-CAM monoclonal antibodies also diminished the formation of multilayered cell aggregates by hOP-1 and decreased cell-cell adhesion when hOP-1-treated NG108-15 cells were dispersed and replated. Thus, hOP-1 produces morphologic changes in NG108-15 cells, at least in part, by inducing N-CAM. These observations suggest that OP-1 or a homologue may participate in the regulation of N-CAM during nervous system development and regeneration.
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