ArticleProceedings of the National Academy of Sciences of the United States of America1992
Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region.European journal of immunology · 2011Article
- Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.Lupus · 2009Article
- Trans-chromosomal recombination within the Ig heavy chain switch region in B lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Ectopic expression of A-myb in transgenic mice causes follicular hyperplasia and enhanced B lymphocyte proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.The Journal of experimental medicine · 1997Article
- The promotion of V region hypermutation.The Journal of experimental medicine · 1997Article
- Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.The Journal of experimental medicine · 1995Article
- Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.The Journal of experimental medicine · 1994Article
- Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.The Journal of experimental medicine · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transgenic lines of mice were derived by using plasmid constructs containing DNA encoding an antibody heavy chain variable-diversity-joining region (VH-D-JH) and various amounts of 5' and 3' flanking DNA but lacking any repetitive isotype switch (S) or constant (C) region DNA. Unexpectedly, many of the antibody VH regions expressed by B-cell hybridomas generated from immunized transgenic mice were found to be of transgenic origin. Further analyses showed that somatic events had generated hybrid genomic loci in the mice containing the transgenic VH-D-JH gene and plasmid sequences 5' of endogenous heavy chain C region genes. Thus, VH-D-JH transgenes lacking S and C region DNA can recombine with endogenous Igh DNA, leading to the expression of transgene-encoded antibody.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.