ArticleProceedings of the National Academy of Sciences of the United States of America1992
Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 259 citations in OpenAlex.
- Hyperhomocysteinemia and the response to vitamin supplementation.The Clinical investigator · 1993Trial
- Independent and Joint Associations of Lipoprotein(a) and Homocysteine with Carotid-Femoral Pulse-Wave Velocity in Adults with Treated Hypertension: A Single-Centre Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Influence of homocysteine on regulating immunothrombosis: mechanisms and therapeutic potential in management of infections.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Metabolites and metabolism in vascular calcification: links between adenosine signaling and the methionine cycle.American journal of physiology. Heart and circulatory physiology · 2024Review
- Review
- Article
- Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID).Biochimica et biophysica acta · 2016Review
- Effects of folic acid supplementation on serum homocysteine and lipoprotein (a) levels during pregnancy.BioImpacts : BI · 2015Article
- The relationship between serum lipoprotein (a) levels and ischemic stroke risk: a cohort study in the Chinese population.Inflammation · 2014Article
- Endothelial dysfunction: the link between homocysteine and hydrogen sulfide.Current medicinal chemistry · 2014Review
- High Lipoprotein(a) Levels are Associated With Long-Term Adverse Outcomes in Acute Myocardial Infarction Patients in High Killip Classes.Korean circulation journal · 2010Article
- Lipoprotein(a), homocysteine, and retinal arteriosclerosis.Molecular vision · 2008Article
- Malnutrition-inflammation-atherosclerosis syndrome in Chronic Kidney disease.Indian journal of clinical biochemistry : IJCB · 2008Article
- Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease.Antioxidants & redox signaling · 2007Review
- Genetic markers and biomarkers for age-related macular degeneration.Expert review of ophthalmology · 2007Article
- Plasma homocysteine and lipoprotein (a) levels in Turkish patients with metabolic syndrome.Heart and vessels · 2005Article
- [Atherosclerosis and uremia: signifance of non-traditional risk factors].Wiener klinische Wochenschrift · 2003Review
- Article
- Homocysteine levels in patients with risk factors for atherosclerosis.Clinical cardiology · 2001Article
- Homocysteine levels in patients with stroke: clinical relevance and therapeutic implications.CNS drugs · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have previously shown that lipoprotein(a) [Lp(a)], an atherogenic lipoprotein that contains apolipoprotein(a), which shares partial structural homology to plasminogen, binds to a plasmin-modified fibrin surface, and we have postulated that this interaction may be atherogenic. Moderate elevations in blood homocysteine, a relatively common condition, predispose to premature atherosclerosis. The reasons for this are not established. We now report that homocysteine, at concentrations as low as 8 microM, significantly increases the affinity of Lp(a) for fibrin. Homocysteine induces a 20-fold increase in the affinity between Lp(a) and plasmin-treated fibrin and a 4-fold increase with unmodified fibrin. Lp(a) binding is inhibited by epsilon-aminocaproic acid, indicating lysine binding site specificity. Homocysteine does not enhance the binding of Lp(a) to other surface-bound proteins. Cysteine, glutathione, and N-acetylcysteine also increase the affinity between Lp(a) and fibrin. Homocysteine does not affect the binding of low density lipoprotein or plasminogen to fibrin, nor does it alter the gel-filtration elution pattern of Lp(a). Immunoblot analysis documents the fact that homocysteine partially reduces Lp(a). These results suggest that homocysteine alters the intact Lp(a) particle so as to increase the reactivity of the plasminogen-like apolipoprotein(a) portion of the molecule. The observation that sulfhydryl amino acids increase Lp(a) binding to fibrin suggests a biochemical relationship between sulfhydryl compound metabolism, thrombosis, and atherogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.