ArticleNucleic acids research1992
RFP is a DNA binding protein associated with the nuclear matrix.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
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- Aberrant Transcriptional Regulation of Super-enhancers by RET Finger Protein-histone Deacetylase 1 Complex in Glioblastoma: Chemoresistance to Temozolomide.Neurologia medico-chirurgica · 2019Review
- Identification of RFPL3 protein as a novel E3 ubiquitin ligase modulating the integration activity of human immunodeficiency virus, type 1 preintegration complex using a microtiter plate-based assay.The Journal of biological chemistry · 2014Article
- DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer.PLoS medicine · 2009Article
- Ret Finger Protein: An E3 Ubiquitin Ligase Juxtaposed to the XY Body in Meiosis.International journal of cell biology · 2009Article
- Novel role of the RET finger protein in estrogen receptor-mediated transcription in MCF-7 cells.Biochemical and biophysical research communications · 2006Article
- Intracellular localization and domain organization of human TRIM41 proteins.Molecular biology reports · 2005Article
- HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells.Molecular and cellular biology · 1999Article
- The Opitz syndrome gene product, MID1, associates with microtubules.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Nuclear matrix, dynamic histone acetylation and transcriptionally active chromatin.Molecular biology reports · 1997Review
- Identification of ErbB3-stimulated genes using modified representational difference analysis.The Biochemical journal · 1997Article
- The nuclear matrix protein NMP-1 is the transcription factor YY1.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.The EMBO journal · 1995Article
- The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.The EMBO journal · 1994Article
- Evolutionary study of multigenic families mapping close to the human MHC class I region.Journal of molecular evolution · 1993Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported that the RFP gene encodes a protein with putative zinc finger domains and was involved in the activation of the ret proto-oncogene. To further characterize the RFP protein, we developed a polyclonal antibody against the product synthesized from a fragment of the RFP cDNA expressed in Escherichia coli. Western blot analysis showed that RFP was identified as a 58 kDa protein in cell lysates from four human and rodent cell lines and from mouse testis. In addition, a unique 68 kDa protein was detected in the testis. Using AH7974 (rat ascites hepatoma) and Raji (human Burkitt lymphoma) cells, we demonstrated strong association of RFP with the nuclear matrix. Furthermore, RFP solubilized from the nuclear matrix had DNA-binding activity although it appears to bind more preferentially to double-stranded DNA than to single-stranded DNA. These results thus suggest that RFP may play a role in molecular processes which occur in the nuclear matrix.
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