ArticleThe Journal of physiology1992
Basal Ca2+ and the oscillation of Ca2+ in caffeine-treated bullfrog sympathetic neurones.
Article in The Journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Axotomy depletes intracellular calcium stores in primary sensory neurons.Anesthesiology · 2009Article
- Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors.The Journal of physiology · 2008Article
- Differential regulation of ER Ca2+ uptake and release rates accounts for multiple modes of Ca2+-induced Ca2+ release.The Journal of general physiology · 2002Article
- Investigation of the role of intracellular Ca(2+) stores in generation of the muscarinic agonist-induced slow afterdepolarization (sADP) in guinea-pig olfactory cortical neurones in vitro.British journal of pharmacology · 2000Article
- Ca2+ influx in resting rat sensory neurones that regulates and is regulated by ryanodine-sensitive Ca2+ stores.The Journal of physiology · 1999Article
- Caffeine-induced [Ca2+] oscillations in neurones of frog sympathetic ganglia.The Journal of physiology · 1999Article
- Effects of injecting calcium-buffer solution on [Ca2+]i in voltage-clamped snail neurons.Biophysical journal · 1996Article
- Calcium-induced calcium release in rat sensory neurons.The Journal of physiology · 1995Article
- Effects of low doses of caffeine on [Ca2+]i in voltage-clamped snail (Helix aspersa) neurones.The Journal of physiology · 1995Article
- Ryanodine receptor-mediated intracellular calcium release in rat cerebellar Purkinje neurones.The Journal of physiology · 1995Article
- Ca(2+)-induced Ca2+ release and its activation in response to a single action potential in rabbit otic ganglion cells.The Journal of physiology · 1995Article
- Characteristics of Ca2+ release induced by Ca2+ influx in cultured bullfrog sympathetic neurones.The Journal of physiology · 1993Article
- Intracellular calcium dynamics in response to action potentials in bullfrog sympathetic ganglion cells.The Journal of physiology · 1992Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Effects of caffeine on the intracellular free Ca2+ concentration ([Ca2+]i) in single bullfrog sympathetic neurones in excised tissue were studied by recording Fura-2 fluorescence excited at 340, 361 or 380 nm and taking their ratios (R340/380 or R361/380). 2. Caffeine (3-10 mM) produced oscillation of [Ca2+]i and an 'apparent' decrease in the basal level of [Ca2+]i during a period between phasic rises. The mechanism of the latter effect was analysed in relation to the mechanism of the former. 3. Caffeine (3-10 mM) increased Fura-2 fluorescence in a range of excitation wavelength from 330 to 390 nm. The ratios of fluorescences, R340/380 and R361/380, however, were not significantly affected by caffeine. These results suggest that the 'apparent' reduction in the basal [Ca2+]i seen as a decrease in R340/380 or R361/380 results from a true decrease in [Ca2+]i. 4. Caffeine-induced decrease in [Ca2+]i persisted for every period between phasic rises of [Ca2+]i during [Ca2+]i oscillation, and after the blockade of [Ca2+]i oscillation by ryanodine. The decrease in the latter condition lasted for more than 20 min. 5. The decrease in the basal [Ca2+]i depended on the external Ca2+ concentration and was not mimicked by the action of cyclic nucleotides. 6. Possible mechanisms underlying the decrease in the basal [Ca2+]i produced by caffeine (effects on Ca2+ transport at the cell or Ca(2+)-storing organelle membrane) and their significance in relation to the [Ca2+]i oscillation were discussed.
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