ArticleThe Journal of physiology1992
Regulation by second messengers of the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes.
Article in The Journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of the PKC inhibitors chelerythrine and bisindolylmaleimide I (GF 109203X) on delayed rectifier K+ currents.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Cross-talk between beta(1)-adrenoceptors and ET(A) receptors in modulation of the slow component of delayed rectifier K(+) currents.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
- Ras pathway activates epithelial Na+ channel and decreases its surface expression in Xenopus oocytes.Molecular biology of the cell · 1998Article
- Inhibition of minK protein induced K+ channels in Xenopus oocytes by estrogens.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Regulation of epithelial ion channels by the cystic fibrosis transmembrane conductance regulator.Journal of molecular medicine (Berlin, Germany) · 1996Review
- Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Effect of isosorbiddinitrate on exogenously expressed slowly activating K+ channels and endogenous K+ channels in Xenopus oocytes.The Journal of physiology · 1996Article
- N-Acetyl-L-cysteine and its derivatives activate a Cl- conductance in epithelial cells.Pflugers Archiv : European journal of physiology · 1996Article
- Protein kinase C consensus sites and the regulation of renal Na/Pi-cotransport (NaPi-2) expressed in XENOPUS laevis oocytes.Pflugers Archiv : European journal of physiology · 1995Article
- Electrophysiological analysis of Na+/Pi cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- K+ currents expressed from the guinea pig cardiac IsK protein are enhanced by activators of protein kinase C.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Species variants of the IsK protein: differences in kinetics, voltage dependence, and La3+ block of the currents expressed in Xenopus oocytes.Pflugers Archiv : European journal of physiology · 1994Article
- The min K channel underlies the cardiac potassium current IKs and mediates species-specific responses to protein kinase C.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
1. Voltage-clamp recordings of membrane current were made from Xenopus oocytes that had been injected with RNA which had been transcribed in vitro from a cloned complementary DNA. 2. Depolarization from -80 mV evoked outward potassium currents that developed very slowly. At -20 mV the time constant for activation was about 50 s, and at +40 mV about 6 s. 3. The potassium current was increased by the calcium ionophore A23187 or by intracellular injection of inositol 1,4,5-trisphosphate (IP3), each of which should increase the intracellular calcium concentration ([Ca2+]i). The current was decreased by injection of BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid). The current was also reduced by phorbol esters; this effect was blocked by staurosporine. 4. In oocytes that had also been injected with RNA encoding the 5-hydroxytryptamine (5-HT2) receptor, 5-HT increased the potassium current. After caffeine pretreatment, to block the release of intracellular calcium, 5-HT decreased the current; this decrease was prevented by staurosporine. 5. It is concluded that the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes is increased by increases in [Ca2+]i and is decreased by activation of protein kinase C. Stimulation of 5-HT2 receptors can have both these effects, but the former normally predominates.
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