ArticleThe Journal of clinical investigation1992
Immune complex processing in patients with systemic lupus erythematosus. In vivo imaging and clearance studies.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis.Rheumatology international · 2011Pooled it
- Meta analysis on the association between FcgammaRIIa-R/H131 polymorphisms and systemic lupus erythematosus.Molecular biology reports · 2009Pooled it
- Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus.Life science alliance · 2022Article
- Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis.Frontiers in cell and developmental biology · 2021Review
- Correlation between Antibodies to Bacterial Lipopolysaccharides and Barrier Proteins in Sera Positive for ASCA and ANCA.International journal of molecular sciences · 2020Article
- Fluctuation of zonulin levels in bloodWorld journal of gastroenterology · 2017Article
- Type I interferonopathies in pediatric rheumatology.Pediatric rheumatology online journal · 2016Review
- Microparticles provide a novel biomarker to predict severe clinical outcomes of dengue virus infection.Journal of virology · 2015Article
- Decreased ITGAM and FcγRIIIA mRNA expression levels in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.Clinical and experimental medicine · 2014Article
- Gene-function studies in systemic lupus erythematosus.Nature reviews. Rheumatology · 2013Review
- Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis.Genes and immunity · 2012Article
- Complement in the immunopathogenesis of rheumatic disease.Nature reviews. Rheumatology · 2012Review
- The atherogenic bacterium Porphyromonas gingivalis evades circulating phagocytes by adhering to erythrocytes.Infection and immunity · 2011Article
- Enhanced neutralization potency of botulinum neurotoxin antibodies using a red blood cell-targeting fusion protein.PloS one · 2011Article
- Markers of childhood lupus nephritis indicating disease activity.Pediatric nephrology (Berlin, Germany) · 2011Article
- Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production.Arthritis and rheumatism · 2011Article
- Complement-4 deficiency in a child with systemic lupus erythematosus presenting with standard treatment-resistant severe skin lesion.ISRN rheumatology · 2011Article
- Copy number, linkage disequilibrium and disease association in the FCGR locus.Human molecular genetics · 2010Article
- Gene-expression profiling in rheumatic disease: tools and therapeutic potential.Nature reviews. Rheumatology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal processing of immune complexes (IC) may be important in the pathogenesis of systemic lupus erythematosus (SLE). The clearance of large soluble IC (comprising hepatitis B surface antigen (HBsAg)/anti-HBsAg) radiolabeled with 123I was examined in 12 normal subjects and 10 patients with SLE. IC localization was analyzed by static and dynamic gamma-scintigraphy. Initial IC clearance from blood was more rapid in patients (median t1/2 = 2.15 min) than normals (median t1/2 = 5.15 min) due to more rapid uptake in the liver. However, in the SLE group, up to 12% of complexes were released from the liver after 30-50 min. Splenic uptake of immune complexes was reduced in the patients and there was reduced ability to retain IC in this organ. Plasma complement levels and erythrocyte complement receptor type 1 numbers were reduced in the patients, resulting in defective opsonization of IC and reduced red cell binding in vivo. These observations support the hypothesis that IC handling is abnormal in SLE.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.