ArticleThe Journal of cell biology1992
Calcium influx into neurons can solely account for cell contact-dependent neurite outgrowth stimulated by transfected L1.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- Cell adhesion and intracellular calcium signaling in neurons.Cell communication and signaling : CCS · 2013Pooled it
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- Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions.Frontiers in cell and developmental biology · 2020Article
- Effects of Xenon-Based Anesthetic Exposure on the Expression Levels of Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) on Human Neural Stem Cell-Derived Neurons.Molecular neurobiology · 2020Article
- Function-triggering antibodies to the adhesion molecule L1 enhance recovery after injury of the adult mouse femoral nerve.PloS one · 2014Article
- Spatiotemporal regulation of the ubiquitinated cargo-binding activity of Rabex-5 in the endocytic pathway.The Journal of biological chemistry · 2012Article
- Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole.Translational psychiatry · 2012Article
- Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.PloS one · 2012Article
- Differential display RT-PCR reveals genes associated with lithium-induced neuritogenesis in SK-N-MC cells.Cellular and molecular neurobiology · 2011Article
- Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth.Cellular and molecular neurobiology · 2010Review
- Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin.The Journal of biological chemistry · 2009Article
- Numb-mediated neurite outgrowth is isoform-dependent, and requires activation of voltage-dependent calcium channels.Neuroscience · 2009Article
- Article
- Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain.The European journal of neuroscience · 2007Article
- Ethanol inhibits L1 cell adhesion molecule activation of mitogen-activated protein kinases.Journal of neurochemistry · 2006Article
- Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.BMC neuroscience · 2005Article
- RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation.The Journal of cell biology · 2005Article
- Secretory phospholipases A2 induce neurite outgrowth in PC12 cells.The Biochemical journal · 2003Article
- The role of endocytic l1 trafficking in polarized adhesion and migration of nerve growth cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Recycling of the cell adhesion molecule L1 in axonal growth cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have used monolayers of control 3T3 cells and 3T3 cells expressing transfected human L1 as a culture substrate for rat PC12 cells and rat cerebellar neurons. PC12 cells and cerebellar neurons extended longer neurites on human L1 expressing cells. Neurons isolated from the cerebellum at postnatal day 9 responded equally as well as those isolated at postnatal day 1-4, and this contrasts with the failure of these older neurons to respond to the transfected human neural cell adhesion molecule (NCAM). Human L1-dependent neurite outgrowth could be blocked by antibodies that bound to rat L1 and, additionally, the response could be fully inhibited by pertussis toxin and substantially inhibited by antagonists of L- and N-type calcium channels. Calcium influx into neurons induced by K+ depolarization fully mimics the L1 response. Furthermore, we show that L1- and K+(-)dependent neurite outgrowth can be specifically inhibited by a reduction in extracellular calcium to 0.25 microM, and by pretreatment of cerebellar neurons with the intracellular calcium chelator BAPTA/AM. In contrast, the response was not inhibited by heparin or by removal of polysialic acid from neuronal NCAM both of which substantially inhibit NCAM-dependent neurite outgrowth. These data demonstrate that whereas NCAM and L1 promote neurite outgrowth via activation of a common CAM-specific second messenger pathway in neurons, neuronal responsiveness to NCAM and L1 is not coordinately regulated via posttranslational processing of NCAM. The fact that NCAM- and L1-dependent neurite outgrowth, but not adhesion, are calcium dependent provides further evidence that adhesion per se does not directly contribute to neurite outgrowth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.