ArticleThe Journal of cell biology1992
An unconventional myosin heavy chain gene from Drosophila melanogaster.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 145 citations in OpenAlex.
- Quantifying bristle cell organization inbioRxiv : the preprint server for biology · 2025Article
- Myosin VI is expressed in developing ovarian follicles inFrontiers in cell and developmental biology · 2025Article
- Functional Characterization of theInternational journal of molecular sciences · 2022Article
- PFTAIRE Kinase L63 Interactor 1A (Pif1A Protein) Is Required for Actin Cone Movement during Spermatid Individualization inInternational journal of molecular sciences · 2022Article
- Diverse functions of myosin VI in spermiogenesis.Histochemistry and cell biology · 2021Review
- salto/CG13164 is required for sperm head morphogenesis in Drosophila.Molecular biology of the cell · 2019Article
- Patterns of chromatin accessibility along the anterior-posterior axis in the early Drosophila embryo.PLoS genetics · 2018Article
- Loss of cargo binding in the human myosin VI deafness mutant (R1166X) leads to increased actin filament binding.The Biochemical journal · 2016Article
- miR-8 modulates cytoskeletal regulators to influence cell survival and epithelial organization in Drosophila wings.Developmental biology · 2016Article
- Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system.Molecular biology of the cell · 2015Article
- A DPP-mediated feed-forward loop canalizes morphogenesis during Drosophila dorsal closure.The Journal of cell biology · 2015Article
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- Extension of a three-helix bundle domain of myosin VI and key role of calmodulins.Biophysical journal · 2011Article
- Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Formation of salt bridges mediates internal dimerization of myosin VI medial tail domain.Structure (London, England : 1993) · 2010Article
- Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila.Molecular biology of the cell · 2010Article
- Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.Nature reviews. Molecular cell biology · 2010Review
- Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis.Oncogene · 2010Article
- Potential roles of myosin VI in cell motility.Biochemical Society transactions · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
As part of a study of cytoskeletal proteins involved in Drosophila embryonic development, we have undertaken the molecular analysis of a 140-kD ATP-sensitive actin-binding protein (Miller, K. G., C. M. Field, and B. M. Alberts. 1989. J. Cell Biol. 109:2963-2975). Analysis of cDNA clones encoding this protein revealed that it represents a new class of unconventional myosin heavy chains. The amino-terminal two thirds of the protein comprises a head domain that is 29-33% identical (60-65% similar) to other myosin heads, and contains ATP-binding, actin-binding and calmodulin/myosin light chain-binding motifs. The carboxy-terminal tail has no significant similarity to other known myosin tails, but does contain a approximately 100-amino acid region that is predicted to form an alpha-helical coiled-coil. Since the unique gene that encodes this protein maps to the polytene map position 95F, we have named the new gene Drosophila 95F myosin heavy chain (95F MHC). The expression profile of the 95F MHC gene is complex. Examination of multiple cDNAs reveals that transcripts are alternatively spliced and encode at least three protein isoforms; in addition, a fourth isoform is detected on Western blots. Developmental Northern and Western blots show that transcripts and protein are present throughout the life cycle, with peak expression occurring during mid-embryogenesis and adulthood. Immunolocalization in early embryos demonstrates that the protein is primarily located in a punctate pattern throughout the peripheral cytoplasm. Most cells maintain a low level of protein expression throughout embryogenesis, but specific tissues appear to contain more protein. We speculate that the 95F MHC protein isoforms are involved in multiple dynamic processes during Drosophila development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.