ArticleThe EMBO journal1992
Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Prevalent Fast Evolution of Genes Involved in Heterochromatin Functions.Molecular biology and evolution · 2024Article
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- Article
- The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.eLife · 2016Article
- A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila.PloS one · 2012Article
- RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila.Molecular biology of the cell · 2007Article
- Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.Genes & development · 2006Article
- The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Drosophila immunity: genes on the third chromosome required for the response to bacterial infection.Genetics · 2001Article
- Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.The EMBO journal · 2000Article
- Article
- Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.Genetics · 2000Article
- Article
- Interactions among dosage-dependent trans-acting modifiers of gene expression and position-effect variegation in Drosophila.Genetics · 1998Article
- Competition between different variegating rearrangements for limited heterochromatic factors in Drosophila melanogaster.Genetics · 1997Article
- The structure of heterochromatic DNA is altered in polyploid cells of Drosophila melanogaster.Molecular and cellular biology · 1997Article
- Article
- Copy number and orientation determine the susceptibility of a gene to silencing by nearby heterochromatin in Drosophila.Genetics · 1996Article
- Mutations of zeste that mediate transvection are recessive enhancers of position-effect variegation in Drosophila melanogaster.Genetics · 1995Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Variegation in Drosophila is a manifest illustration of the important role played by chromatin structure in gene expression. We have isolated mutants of modulo (mod) and shown that this gene is a dominant suppressor of variegation. Null mutants are recessive lethal with a melanotic tumour phenotype. The mod protein directly binds DNA, which indicates that it may serve to anchor multimeric complexes promoting chromatin compaction and silencing. Using a specific monoclonal antibody we examined by immunocytochemistry the accumulation pattern of mod protein during embryogenesis. The protein is first detected before the blastoderm cellularization in all somatic nuclei, precisely when pericentromeric heterochromatin becomes visible. After the first cell division, mod protein is expressed in lineages of specific embryonic primordia. Based on its dominant phenotype, expression pattern and DNA-binding activity of its product, we propose that mod regulates chromatin structure and activity in specific cell lineages.
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