ArticleThe EMBO journal1992
Hemin uptake system of Yersinia enterocolitica: similarities with other TonB-dependent systems in gram-negative bacteria.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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Who cites it
122 citing papers in PubMed, 256 citations in OpenAlex.
- Biochemical and functional characterization ofFrontiers in microbiology · 2026Article
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- Exploring heme and iron acquisition strategies of Porphyromonas gingivalis-current facts and hypotheses.FEMS microbiology reviews · 2025Review
- HmuY proteins of theFrontiers in cellular and infection microbiology · 2025Article
- Involvement of HemI, an ECF sigma factor, in hemin acquisition and antibiotic susceptibility inFrontiers in cellular and infection microbiology · 2025Article
- Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution.Microbiology and molecular biology reviews : MMBR · 2024Review
- AApplied and environmental microbiology · 2023Article
- Involvement of theMicrobiology spectrum · 2022Article
- Characterisation ofJournal of veterinary research · 2022Article
- Innate Bacteriostatic Mechanisms Defend the Urinary Tract.Annual review of physiology · 2022Review
- The Regulatory Protein ChuP Connects Heme and Siderophore-Mediated Iron Acquisition Systems Required forFrontiers in cellular and infection microbiology · 2022Article
- Article
- Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics.Chemical reviews · 2021Review
- Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica.BMC biology · 2021Article
- Article
- The Regulator OmpR inInternational journal of molecular sciences · 2021Article
- Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Rapid Uptake and Photodynamic Inactivation of Staphylococci by Ga(III)-Protoporphyrin IX.ACS infectious diseases · 2018Article
- Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus.Journal of microbiology (Seoul, Korea) · 2018Article
62 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hemin receptor HemR of Yersinia enterocolitica was identified as a 78 kDa iron regulated outer membrane protein. Cells devoid of the HemR receptor as well as cells mutated in the tonB gene were unable to take up hemin as an iron source. The hemin uptake operon from Y. enterocolitica was cloned in Escherichia coli K12 and was shown to encode four proteins: HemP (6.5 kDa), HemR (78 kDa), HemS (42 kDa) and HemT (27 kDa). When expressed in E.coli hemA aroB, a plasmid carrying genes for HemP and HemR allowed growth on hemin as a porphyrin source. Presence of genes for HemP, HemR and HemS was necessary to allow E.coli hemA aroB cells to use hemin as an iron source. The nucleotide sequence of the hemR gene and its promoter region was determined and the amino acid sequence of the HemR receptor deduced. HemR has a signal peptide of 28 amino acids and a typical TonB box at its amino-terminus. Upstream of the first gene in the operon (hemP), a well conserved Fur box was found which is in accordance with the iron-regulated expression of HemR.
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