ArticleThe EMBO journal1992
Emergence of committed B lymphoid progenitors in the developing chicken embryo.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 99 citations in OpenAlex.
- Article
- Transcriptome analysis identifies CCR7 and cell adhesion molecules as mediators of B cell migration to the bursa of Fabricius during chicken embryonic development.BMC genomics · 2025Article
- Role of Physiology, Immunity, Microbiota, and Infectious Diseases in the Gut Health of Poultry.Vaccines · 2022Review
- Identification, tissue characterization, and innate immune role of Angiogenin-4 expression in young broiler chickens.Poultry science · 2020Article
- Effect of methionine deficiency on duodenal and jejunal IgAIranian journal of veterinary research · 2018Article
- Toxicological effects of nickel chloride on IgA+ B Cells and sIgA, IgA, IgG, IgM in the intestinal mucosal immunity in broilers.International journal of environmental research and public health · 2014Article
- Specific tumor-stroma interactions of EBV-positive Burkitt's lymphoma cells in the chick chorioallantoic membrane.Vascular cell · 2012Article
- The ontogeny of the porcine immune system.Developmental and comparative immunology · 2009Review
- Ligand-independent signaling during early avian B cell development.Immunologic research · 2006Review
- Article
- Development of B cells expressing surface immunoglobulin molecules that lack V(D)J-encoded determinants in the avian embryo bursa of fabricius.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Fetal lambs are depleted of IgM+ cells following a single injection of an anti-IgM antibody early in gestation.Immunology · 1996Article
- The chicken immunoglobulin lambda light chain gene is transcriptionally controlled by a modularly organized enhancer and an octamer-dependent silencer.Nucleic acids research · 1995Article
- Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Loss of surface immunoglobulin expression precedes B cell death by apoptosis in the bursa of Fabricius.The Journal of experimental medicine · 1995Article
- Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.The EMBO journal · 1994Article
- Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene.The EMBO journal · 1993Article
- Ontogeny of leucocyte populations in the spleen of fetal lambs with emphasis on the early prominence of B cells.Immunology · 1993Article
- Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- At day 8-8.5 of mouse development the yolk sac, not the embryo proper, has lymphoid precursor potential in vivo and in vitro.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of B lymphoid restricted progenitors was followed during chicken embryonic development by monitoring the appearance of the various Ig gene rearrangements (DJH, VHDJH, V lambda J lambda), as a sensitivity that allows the detection of a single rearranged cell. By quantifying the DJH committed progenitor populations, we describe their evolution in different compartments at different developmental stages. The yolk sac is the first site where DJH-positive cells are observed (at days 5-6 of development); via the general circulation, they then seed the various organs while undergoing VHDJH and V lambda J lambda rearrangements, which occur simultaneously but lag behind DJH by one to several days. These progenitor populations decline with time in most lymphoid sites and only expand in the bursa. RAG-1 expression is observed in the bursa in the absence of ongoing rearrangement activity and thus appears to be an improper marker of rearrangement in the chicken. Commitment to the B cell lineage seems to result from an intrinsic cell program, but the survival and expansion of the committed B progenitors require the specific microenvironment of the bursa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.