ReviewCancer metastasis reviews1992
The plasminogen-plasmin system in malignancy.
Review in Cancer metastasis reviews, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 191 citations in OpenAlex.
- Do coagulation or fibrinolysis reflect the disease condition in patients with soft tissue sarcoma?BMC cancer · 2022Article
- Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors.BMC cancer · 2021Article
- Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones.The Journal of biological chemistry · 2017Article
- Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10.Oncotarget · 2016Article
- A novel uPAg-KPI fusion protein inhibits the growth and invasion of human ovarian cancer cells in vitro.International journal of molecular medicine · 2016Article
- Cancer and venous thromboembolic disease: from molecular mechanisms to clinical management.Current oncology (Toronto, Ont.) · 2014Review
- Clinical significance of annexin II expression in human non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Upregulated expression of annexin II is a prognostic marker for patients with gastric cancer.World journal of surgical oncology · 2012Article
- The biochemistry and regulation of S100A10: a multifunctional plasminogen receptor involved in oncogenesis.Journal of biomedicine & biotechnology · 2012Review
- The role of annexin A2 in tumorigenesis and cancer progression.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011Article
- Impact of venous thromboembolism and anticoagulation on cancer and cancer survival.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009Review
- High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma.World journal of surgery · 2007Article
- Plasminogen activation/plasmin in rheumatoid arthritis: matrix degradation and more.The American journal of pathology · 2005Article
- Tissue plasminogen activator is a potent activator of PDGF-CC.The EMBO journal · 2004Article
- Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice.The American journal of pathology · 2001Article
- A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation.Nature cell biology · 2001Article
- Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains.EMBO reports · 2000Article
- The plasmin system is induced by and degrades amyloid-beta aggregates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis.British journal of cancer · 2000Article
- Proteolysis in human breast cancer.Molecular pathology : MP · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of the plasminogen-plasmin system has, in the past, contributed much to the understanding of fibrinolysis and thrombolysis. Attention is now focused on the role of the components of this system in many biologic functions. Findings of uPA, its receptor and its inhibitor in many tumor tissues and tumor cell lines, strongly implicate their involvement in tumor invasion, tumor cell proliferation and metastasis. The characteristics of the plasminogen activators, the uPA receptor and the plasminogen activator inhibitors as well as their expression and regulation in tumors and tumor cell lines are reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.