ArticleCell and tissue research1992
Immunolocalization of synexin (annexin VII) in adrenal chromaffin granules and chromaffin cells: evidence for a dynamic role in the secretory process.
Article in Cell and tissue research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Role of annexin A7 in the occurrence and progression of coronary atherosclerosis: a narrative review.Cardiovascular diagnosis and therapy · 2025Review
- Transcriptome analysis reveals miRNA expression profiles in hypothalamus tissues during the sexual development of Jining grey goats.BMC genomics · 2024Article
- A Dominant-Negative Mutant of ANXA7 Impairs Calcium Signaling and Enhances the Proliferation of Prostate Cancer Cells by Downregulating the IP3 Receptor and the PI3K/mTOR Pathway.International journal of molecular sciences · 2023Article
- A Temporal Comparative RNA Transcriptome Profile of the Annexin Gene Family in the Salivary versus Lacrimal Glands of the Sjögren's Syndrome-Susceptible C57BL/6.NOD-International journal of molecular sciences · 2022Article
- Annexins and cardiovascular diseases: Beyond membrane trafficking and repair.Frontiers in cell and developmental biology · 2022Review
- Annexin Animal Models-From Fundamental Principles to Translational Research.International journal of molecular sciences · 2021Review
- Article
- Annexins in Adipose Tissue: Novel Players in Obesity.International journal of molecular sciences · 2019Review
- Influence of annexin A7 on insulin sensitivity of cellular glucose uptake.Pflugers Archiv : European journal of physiology · 2015Article
- Article
- Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7.Pflugers Archiv : European journal of physiology · 2010Article
- Nuclear localization of Annexin A7 during murine brain development.BMC neuroscience · 2005Article
- Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes.Molecular and cellular biology · 2001Article
- ANX7, a candidate tumor suppressor gene for prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Is annexin 7 a tumor suppressor gene in prostate cancer?The pharmacogenomics journal · 2001Article
- Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Expression and localisation of annexin VII (synexin) isoforms in differentiating myoblasts.Journal of muscle research and cell motility · 1999Article
- Membrane fusion protein synexin (annexin VII) as a Ca2+/GTP sensor in exocytotic secretion.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Novel isoforms of synexin in Xenopus laevis: multiple tandem PGQM repeats distinguish mRNAs in specific adult tissues and embryonic stages.The Biochemical journal · 1996Article
- Genomic organization and chromosomal localization of the mouse synexin gene.The Biochemical journal · 1994Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synexin (annexin VII) is a Ca(2+)- and phospholipid-binding protein which has been proposed to play a role in Ca(2+)-dependent membrane fusion processes. Using a monoclonal antibody against synexin, Mab 10E7, and immunogold, we carried out a semiquantitative localization study of synexin in bovine adrenal medullary chromaffin granules, and in resting and nicotine-stimulated adrenal chromaffin cells. Isolated chromaffin granules contained very little synexin, whereas chromaffin granules aggregated with synexin (24 micrograms/mg) and Ca2+ (1 mM) clearly showed synexin-associated immunogold particles in the vicinity of the granule membrane (1.88 gold particles per granule profile). In isolated, cultured adrenal chromaffin cells, synexin was present in the nucleus (5.5 particles/microns 2) and in the cytosol (5.3 particles/microns 2), but mainly around the granule membrane in the granular cell area (11.7 particles/microns 2). During the active phase of cholinergically stimulated catecholamine secretion, the amount of synexin label was reduced by 33% in the nucleus, by 23% in the cytosol, and by 51% in the granule area. The plasma membrane contained a small amount of synexin, which did not significantly change upon stimulation of the cells. We conclude that synexin is involved in the secretory process in chromaffin cells.
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