ArticleCell and tissue research1992
Differential expression of four genes encoding molluscan insulin-related peptides in the central nervous system of the pond snail Lymnaea stagnalis.
Article in Cell and tissue research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- Photoperiodic control of the albumen gland by neurosecretory canopy cells in the pond snail Lymnaea stagnalis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Unique morphology and photoperiodically regulated activity of neurosecretory canopy cells in the pond snail Lymnaea stagnalis.Cell and tissue research · 2023Article
- Characterization of Insulin-like Peptide (ILP) and Its Potential Role in Ovarian Development of the CuttlefishCurrent issues in molecular biology · 2022Article
- Insulin and Memory in Invertebrates.Frontiers in behavioral neuroscience · 2022Review
- Effect of photoperiod and light intensity on learning ability and memory formation of the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- An immunohistochemical analysis of peptidergic neurons apparently associated with reproduction and growth in Biomphalaria alexandrina.General and comparative endocrinology · 2019Article
- Consolidation of long-term memory by insulin in Lymnaea is not brought about by changing the number of insulin receptors.Communicative & integrative biology · 2013Article
- Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- RNA molecules lighting up under the microscope.Histochemistry and cell biology · 1996Review
- Functional morphology of the neuropeptidergic light-yellow-cell system in pulmonate snails.Cell and tissue research · 1994Article
- Axonal localization of neuropeptide-encoding mRNA in identified neurons of the snail Lymnaea stagnalis.Cell and tissue research · 1994Article
- Functional morphology of the light yellow cell and yellow cell (sodium influx-stimulating peptide) neuroendocrine systems of the pond snail Lymnaea stagnalis.Cell and tissue research · 1994Article
- The isolation of a cDNA encoding a neuropeptide prohormone from the light yellow cells of Lymnaea stagnalis.Cellular and molecular neurobiology · 1993Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the pond snail Lymnaea stagnalis, the growth regulating system consists of (1) about 200 neuroendocrine light green cells, located in four clusters in the cerebral ganglia, and (2) the paired canopy cells, located in the lateral lobes. These cells express genes encoding the molluscan insulin-related peptides (MIPs). Six MIP genes have previously been identified. Four of these (I, II, III and V) are expressed in the light green cells and the canopy cells. The MIP-VI gene is a pseudogene. In the present in situ hybridization study, using oligonucleotide probes specific to the transcripts of MIP-I, -II, -III, -IV and -V, no signal was obtained with the MIP-IV probe, indicating that gene IV is also a pseudogene. With the other four probes, two types of light green cells were distinguished. Type-A cells express all four MIP genes, whereas type-B cells do not (or only faintly) express the MIP-I gene. Gene III is relatively strongly expressed in type-B cells. Genes II and V are moderately expressed in both cell types. Type-A cells are mainly located in the periphery of the clusters, whereas type-B cells are present in the center. The canopy cell resembles type-A light green cells. The expression levels of the MIP-II and MIP-V genes are low in the canopy cell. The expression pattern of the MIP genes correlates with the staining pattern of the anti-MIP-C antibody, which has been raised to a synthetic C-fragment shared by MIP-I, -II and -V. Type-A cells stain more intensely with the antibody than type-B cells.
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