ReviewClinical microbiology reviews1992
Dysregulation of strongyloidiasis: a new hypothesis.
Review in Clinical microbiology reviews, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 169 citations in OpenAlex.
- Words and Worms: The Nosology of Strongyloidiasis.The American journal of tropical medicine and hygiene · 2026Review
- Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system.PLoS neglected tropical diseases · 2026Article
- Bridging experimental biology and clinical practice: lessons from autoinfective larvae ofJournal of clinical microbiology · 2025Article
- Human strongyloidiasis: complexities and pathways forward.Clinical microbiology reviews · 2023Review
- Route of dexamethasone administration influences parasite burden inJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Case Report: Duodenal Papillary Stenosis Secondary to Strongyloides stercoralis Infection in a Non-Immunocompromised Host.The American journal of tropical medicine and hygiene · 2023Article
- Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic.Pathogens (Basel, Switzerland) · 2023Article
- Coinfection withTropical medicine and infectious disease · 2023Review
- Seroprevalence of Strongyloides infection among steroid recipients in a tertiary care centre in North India.Le infezioni in medicina · 2022Article
- Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis.PloS one · 2021Article
- Direct detection of Strongyloides infection via molecular and antigen detection methods.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Review
- Descriptive Investigation of Strongyloidiasis Infection and Characterization ofCase reports in infectious diseases · 2020Article
- Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis.Tropical medicine and infectious disease · 2019Article
- Argument for Inclusion of Strongyloidiasis in the Australian National Notifiable Disease List.Tropical medicine and infectious disease · 2018Review
- Inflammatory and infectious manifestations of immunodeficiency in the gastrointestinal tract.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Review
- The Unique Life Cycle of Strongyloides stercoralis and Implications for Public Health Action.Tropical medicine and infectious disease · 2018Review
- Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses,Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Human infection with Strongyloides stercoralis and other related Strongyloides species.Parasitology · 2017Review
- Severe strongyloidiasis with negative serology after corticosteroid treatment.The American journal of case reports · 2015Article
- Strongyloides stercoralis infection in marmosets: replication of complicated and uncomplicated human disease and parasite biology.Parasites & vectors · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few other human parasites are associated with such a diverse spectrum of clinical manifestations as Strongyloides stercoralis, yet the basic biological behavior of this unusually versatile worm, particularly with respect to its ability to cause severe disseminated disease in certain hosts, is poorly understood. The current uncritical acceptance of the theory that cell-mediated immunity controls autoinfection has stifled research in other directions. After reviewing what is and is not known about the parasite's behavior in its host, this article explores some of the mechanisms that could be involved in the regulation of the parasite population. Taking the provocative viewpoint that the parasite, not the host, is mainly responsible for the maintenance of a balanced relationship between the two, I propose a new theory that corticosteroids may act on the intraintestinal larvae as molting hormones and directly promote the development of disseminated disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.