ArticleBreast cancer research and treatment1992
Expression of IGF-I and IGF-II mRNA in breast tissue.
Article in Breast cancer research and treatment, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 109 citations in OpenAlex.
- Effect of two-4-hydroxyandrostenedione doses on serum insulin-like growth factor I levels in advanced breast cancer.Breast cancer research and treatment · 1994Trial
- The Mammary Gland: Basic Structure and Molecular Signaling during Development.International journal of molecular sciences · 2022Review
- Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study.BMC cancer · 2020Article
- Tumor Phenotype and Gene Expression During Early Mammary Tumor Development in Offspring Exposed to Alcohol In Utero.Alcoholism, clinical and experimental research · 2016Article
- IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway.Oncotarget · 2016Article
- The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors.Breast cancer research : BCR · 2013Article
- IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients.BMC medicine · 2010Article
- Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.Endocrinology · 2009Article
- Article
- IGF ligand and receptor regulation of mammary development.Journal of mammary gland biology and neoplasia · 2008Review
- Acromegaly: re-thinking the cancer risk.Reviews in endocrine & metabolic disorders · 2008Review
- The mRNA expression of IGF-1 and IGF-1R in human breast cancer: association with clinico-pathological parameters.Journal of carcinogenesis · 2006Article
- Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function.Breast cancer research : BCR · 2002Review
- Insulin-like growth factor binding proteins (IGFBPs) in breast cancer.Journal of mammary gland biology and neoplasia · 2000Review
- Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.Breast cancer research : BCR · 2000Review
- Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas.British journal of cancer · 1997Article
- Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone.British journal of cancer · 1997Article
- Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer.British journal of cancer · 1996Article
- IGF-II mRNA and protein are expressed in the stroma of invasive breast cancers: an in situ hybridization and immunohistochemistry study.Breast cancer research and treatment · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both the malignant epithelial cells and their adjacent stromal cells. These data imply that stromal cells associated with breast epithelium may switch expression from IGF-I to IGF-II during breast cancer evolution. This appearance of IGF-II expression may identify cancer-associated stromal cells that have a fetal phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.