ArticleBiophysical journal1992
How do selectins mediate leukocyte rolling in venules?
Article in Biophysical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 136 citations in OpenAlex.
- A humanized βCell reports · 2022Article
- Role of deformable cancer cells on wall shear stress-associated-VEGF secretion by endothelium in microvasculature.PloS one · 2019Article
- Effect of Pseudopod Extensions on Neutrophil Hemodynamic Transport Near a Wall.Cellular and molecular bioengineering · 2016Article
- Neutrophil rolling at high shear: flattening, catch bond behavior, tethers and slings.Molecular immunology · 2013Review
- Numerical simulation of passage of a neutrophil through a rectangular channel with a moderate constriction.PloS one · 2013Article
- Forces on a wall-bound leukocyte in a small vessel due to red cells in the blood stream.Biophysical journal · 2012Article
- Bistability of cell adhesion in shear flow.Biophysical journal · 2011Article
- Leukocyte rolling on engineered nanodot surfaces.Micro & nano letters · 2011Article
- Biomechanics of leukocyte rolling.Biorheology · 2011Review
- A semianalytical model to study the effect of cortical tension on cell rolling.Biophysical journal · 2010Article
- Nano-motion dynamics are determined by surface-tethered selectin mechanokinetics and bond formation.PLoS computational biology · 2009Article
- Micro-PTV measurement of the fluid shear stress acting on adherent leukocytes in vivo.Biophysical journal · 2009Article
- Event-tracking model of adhesion identifies load-bearing bonds in rolling leukocytes.Microcirculation (New York, N.Y. : 1994) · 2009Article
- Leukocyte adhesion molecules in animal models of inflammatory bowel disease.Inflammatory bowel diseases · 2008Review
- Integrin VLA-4 enhances sialyl-Lewisx/a-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions.American journal of physiology. Cell physiology · 2008Article
- Dynamics of in silico leukocyte rolling, activation, and adhesion.BMC systems biology · 2007Article
- Microparticle adhesive dynamics and rolling mediated by selectin-specific antibodies under flow.Biotechnology and bioengineering · 2007Article
- Simultaneous tether extraction contributes to neutrophil rolling stabilization: a model study.Biophysical journal · 2007Article
- A semianalytic model of leukocyte rolling.Biophysical journal · 2004Article
- Dynamic contact forces on leukocyte microvilli and their penetration of the endothelial glycocalyx.Biophysical journal · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
At the onset of inflammation, 20-80% of all leukocytes passing postcapillary venules roll along the endothelium. Recent blocking experiments with antibodies and soluble adhesion receptor molecules, as well as in vitro reconstitution experiments, suggest that leukocyte rolling is mediated by adhesion molecules that belong to the selectin family. What differentiates a selectin-counterreceptor interaction that leads to leukocyte rolling from others that mediate firm adhesion after static incubation but no adhesion when incubated under flow conditions? Here, we explore this question by introducing a quantitative biophysical model that is compatible with the laws of mechanics as applied to rolling leukocytes and the present biochemical and biophysical data on selectin mediated interactions. Our computational experiments point to an adhesion mechanism in which the rate of bond formation is high and the detachment rate low, except at the rear of the contact area where the stretched bonds detach at a high uniform rate. The bond length and bond flexibility play a critical role in enhancing leukocyte rolling at a wide range of fluid shear rates.
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Registered trials
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