ArticleBritish journal of cancer1992
Induction of HSP70 is associated with vincristine resistance in heat-shocked 9L rat brain tumour cells.
Article in British journal of cancer, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 37 citations in OpenAlex.
- Overexpression of Heat Shock Transcription Factor 1 enhances the resistance of melanoma cells to doxorubicin and paclitaxel.BMC cancer · 2013Article
- The contribution of c-Jun N-terminal kinase activation and subsequent Bcl-2 phosphorylation to apoptosis induction in human B-cells is dependent on the mode of action of specific stresses.Toxicology and applied pharmacology · 2008Article
- Drug resistance and apoptosis in ENU-induced rat brain tumors treated with anti-cancer drugs.Journal of neuro-oncology · 1998Article
- Heat shock protein expression in testis and bladder cancer cell lines exhibiting differential sensitivity to heat.British journal of cancer · 1995Article
- Characterisation of a navelbine-resistant bladder carcinoma cell line cross-resistant to taxoids.British journal of cancer · 1994Article
- Drug resistance in brain tumors.Journal of neuro-oncology · 1994Review
- Characterisation of a vindesine-resistant human small-cell lung cancer cell line.British journal of cancer · 1993Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most prominent cellular changes in heat-shock response are induction of HSPs synthesis and reorganisation of cytoskeleton. Vincristine was used as a tool to evaluate the integrity of microtubules in 9L rat brain tumour cells recovering from heat-shock treatment. Cells treated at 45 degrees C for 15 min and recovered under normal growing condition became resistant to vincristine-inflicted cytotoxicity and microtubule destruction. Among all HSPs, the level of HSP70 and the degree of vincristine resistance are best correlated. HSP70 and tubulin were found to be associated with each other as they were co-immunoprecipitated by either anti-HSP70 or anti-beta-tubulin monoclonal antibody. The current studies establish for the first time that HSP70 can complex with tubulin in cells and this association may stabilise the organisation of microtubules thus protect the heat-treated cells from vincristine damage. These findings are noteworthy in combining hyperthermia and chemotherapy in the management of malignant diseases.
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