ArticleBritish journal of cancer1992
p53 expression in Reed-Sternberg cells of Hodgkin's disease.
Article in British journal of cancer, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 34 citations in OpenAlex.
- Expression and prognostic significance of Cox-2 and p-53 in Hodgkin lymphomas: a retrospective study.Diagnostic pathology · 2010Article
- p53 mutation and expression in lymphoma.British journal of cancer · 1995Article
- Expression of bcl-2 and p53 proteins in nasopharyngeal carcinoma. Absence of correlation with the presence of EBV encoded EBER1-2 transcripts and latent membrane protein-1.Clinical molecular pathology · 1995Article
- Mutation of p53 in primary biopsy material and cell lines from Hodgkin disease.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
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Abstract
Mutation of the p53 protein may represent the commonest genetic event in human malignancy. Abnormal p53 expression has been reported in a variety of carcinomas, sarcomas and lymphoid neoplasms; however there is little information in relation to Hodgkin's disease. The expression of the nuclear phosphoprotein was investigated in paraffin-embedded biopsies from fifty patients with Hodgkin's disease using a polyclonal antibody, CM-1 and in snap-frozen material with monoclonal antibodies, PAb 1801 and PAb 240. Specifically, immunoreactivity was localised to the Reed-Sternberg cells or mononuclear variants in both nodular sclerosing (86% cases) and mixed cellularity (57% cases) subtypes of Hodgkin's disease. However, no positive staining was found in our cases of nodular lymphocyte predominant type Hodgkin's disease. Serial biopsies following recurrence of disease demonstrated consistent results. It is suggested that overexpression of p53, probably mutant, may have a role in the tumorigenesis of Hodgkin's disease.
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