ArticleThe Biochemical journal1992
Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.
Article in The Biochemical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- GSTT2 Switches from a Homeostatic Antioxidant to a Cell-Cycle-Coupled Factor in Therapy-Resistant Esophageal Adenocarcinoma.Cancers · 2026Article
- Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Response to Bacillus Calmette-Guérin Immunotherapy in Bladder Cancer Patients.International journal of molecular sciences · 2024Article
- Proanthocyanidins mitigate bile acid-induced changes in GSTT2 levels in a panel of racially diverse patient-derived primary esophageal cell cultures.Molecular carcinogenesis · 2022Article
- A proteome-wide atlas of lysine-reactive chemistry.Nature chemistry · 2021Article
- Gene expression profiles in human peripheral blood mononuclear cells as biomarkers for nutritional in vitro and in vivo investigations.Genes & nutrition · 2010Article
- Investigation of glutathione S-transferase M1 and T1 deletions in lung cancer.Molecular biology reports · 2010Article
- Intervention with cloudy apple juice results in altered biological activities of ileostomy samples collected from individual volunteers.European journal of nutrition · 2008Article
- GSTT2 promoter polymorphisms and colorectal cancer risk.BMC cancer · 2007Article
- Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates.The Biochemical journal · 2005Article
- Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.The Biochemical journal · 2002Article
- Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract.Japanese journal of cancer research : Gann · 2000Article
- Mutagenic analysis of conserved arginine residues in and around the novel sulfate binding pocket of the human Theta class glutathione transferase T2-2.Protein science : a publication of the Protein Society · 1999Article
- Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1.The Biochemical journal · 1999Article
- Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.The Biochemical journal · 1998Article
- Glutathione S-transferases of the yeast Yarrowia lipolytica have unusually large molecular mass.The Biochemical journal · 1998Article
- Effect of glutathione S-transferase M1 polymorphisms on biomarkers of exposure and effects.Environmental health perspectives · 1998Review
- Zeta, a novel class of glutathione transferases in a range of species from plants to humans.The Biochemical journal · 1997Article
- Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse. Comparison of the tissue distribution of GST T1-1 with that of classes Alpha, Mu and Pi GST in human.The Biochemical journal · 1997Article
- The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics.Environmental health perspectives · 1997Review
- Glutathione S-transferases from the white-rot fungus, Phanerochaete chrysosporium.The Biochemical journal · 1997Article
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2 authors.
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Abstract
A purification scheme is described for a glutathione S-transferase (GST) from human liver that catalyses the conjugation of 1-menaphthyl sulphate (MS) with GSH; the method devised results in an approx. 500-fold increase in specific activity towards MS. The human enzyme which metabolizes MS is a homodimer comprising subunits of M(r) 25,100, and immunochemical experiments have shown it to be a member of the class-Theta GSTs. Automated Edman degradation of this enzyme has confirmed that it is a Theta-class GST bu the amino acid sequence obtained differs from that of GST theta described previously [Meyer, Coles, Pemble, Gilmore, Fraser & Ketterer (1991) Biochem. J. 274, 409-414]. We have therefore designated the enzyme that catalyses the conjugation of MS with GSH GST T2-2* (in the absence of complete amino acid sequence data, the T1 and T2 subunits are provisionally designated T1* and T2*); the evidence which indicates that GST theta (which should possibly now be called GST T1-1*) and GST T2-2* represent distinct isoenzymes is discussed.
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