ArticleAntimicrobial agents and chemotherapy1992
Analysis of vancomycin time-kill studies with Staphylococcus species by using a curve stripping program to describe the relationship between concentration and pharmacodynamic response.
Article in Antimicrobial agents and chemotherapy, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The clinical efficacy and safety of vancomycin loading dose: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Association between the AUC0-24/MIC Ratio of Vancomycin and Its Clinical Effectiveness: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Constant rate infusion of vancomycin in premature neonates: a new dosage schedule.British journal of clinical pharmacology · 1998Trial
- Comparison of conventional dosing versus continuous-infusion vancomycin therapy for patients with suspected or documented gram-positive infections.Antimicrobial agents and chemotherapy · 1996Trial
- Review
- Effect of Vancomycin Loading Doses on the Attainment of Target Trough Concentrations in Hospitalized Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Efficacious Analogs of the Lantibiotic Mutacin 1140 against a Systemic Methicillin-Resistant Staphylococcus aureus Infection.Antimicrobial agents and chemotherapy · 2018Article
- Alternative strategies for proof-of-principle studies of antibacterial agents.Antimicrobial agents and chemotherapy · 2014Review
- Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation.The open microbiology journal · 2013Article
- Effect of coadministration of vancomycin and BMP-2 on cocultured Staphylococcus aureus and W-20-17 mouse bone marrow stromal cells in vitro.Antimicrobial agents and chemotherapy · 2012Article
- Development and validation of a novel vancomycin dosing nomogram for achieving high-target trough levels at 2 canadian teaching hospitals.The Canadian journal of hospital pharmacy · 2012Article
- In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureus severe respiratory infections.BMC infectious diseases · 2007Article
- A review of the current place of glycopeptides in turkish medical practice.Current therapeutic research, clinical and experimental · 2007Review
- Impaired target site penetration of vancomycin in diabetic patients following cardiac surgery.Antimicrobial agents and chemotherapy · 2006Article
- Levels of vancomycin in the cerebral interstitial fluid after severe head injury.Intensive care medicine · 2006Article
- The management of infection and colonization due to methicillin-resistant Staphylococcus aureus: A CIDS/CAMM position paper.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 2004Article
- In vitro synergistic effects of double and triple combinations of beta-lactams, vancomycin, and netilmicin against methicillin-resistant Staphylococcus aureus strains.Antimicrobial agents and chemotherapy · 2000Article
- In vitro studies of pharmacodynamic properties of vancomycin against Staphylococcus aureus and Staphylococcus epidermidis.Antimicrobial agents and chemotherapy · 1998Article
- Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus.Antimicrobial agents and chemotherapy · 1998Article
- Pharmacodynamics of vancomycin alone and in combination with gentamicin at various dosing intervals against methicillin-resistant Staphylococcus aureus-infected fibrin-platelet clots in an in vitro infection model.Antimicrobial agents and chemotherapy · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mono- and biexponential killing curves for vancomycin over a 2- to 50-micrograms/ml concentration range were generated for 11 Staphylococcus aureus isolates and 12 coagulase-negative Staphylococcus species in the logarithmic phase of growth. Nonlinear least-squares regression of the initial growth rate and disappearance were not significantly different for lower or higher concentrations of vancomycin in broth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.