ArticleAnatomy and embryology1992
Schwann cells are not required for guidance of motor nerves in the hindlimb in Splotch mutant mouse embryos.
Article in Anatomy and embryology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- GFRα1 Promotes Axon Regeneration after Peripheral Nerve Injury by Functioning as a Ligand.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- PAX Genes in Cardiovascular Development.International journal of molecular sciences · 2022Review
- Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury.NPJ Regenerative medicine · 2022Article
- Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration.Frontiers in neuroscience · 2020Review
- Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves.Frontiers in molecular neuroscience · 2019Review
- Comparison of the Effects of BMSC-derived Schwann Cells and Autologous Schwann Cells on Remyelination Using a Rat Sciatic Nerve Defect Model.International journal of biological sciences · 2018Article
- After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The repair Schwann cell and its function in regenerating nerves.The Journal of physiology · 2016Review
- Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells.Cold Spring Harbor perspectives in biology · 2015Review
- Schwann Cells: Development and Role in Nerve Repair.Cold Spring Harbor perspectives in biology · 2015Review
- Cochleovestibular nerve development is integrated with migratory neural crest cells.Developmental biology · 2014Article
- Comparing peripheral glial cell differentiation in Drosophila and vertebrates.Cellular and molecular life sciences : CMLS · 2011Review
- Schwann cells proliferate at rat neuromuscular junctions during development and regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Outgrowing nerves in the foreleg of a mouse embryo as viewed by three-dimensional reconstruction from electron micrographs.Cell and tissue research · 1995Article
- The Splotch (Sp1H) and Splotch-delayed (Spd) alleles: differential phenotypic effects on neural crest and limb musculature.Anatomy and embryology · 1993Article
- The Splotch mutation interferes with muscle development in the limbs.Anatomy and embryology · 1993Article
- Role of Schwann cells in the regeneration of penile and peripheral nerves.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The topogenesis of the hindlimb nerves of Splotch homozygous mutant mouse embryos was studied using light and electron microscopy. Homozygous mutants show multiple defects of neural crest-derived tissues. The defects increase along a rostro-caudal gradient. The cervical and upper thoracic segments have small spinal ganglia, and Schwann cells are associated with the spinal nerves. In the lumbo-sacral region neurulation is not complete, and the derivatives of the neural crest are missing. The lumbo-sacral nerve trunks are formed by ventral roots only. They are occasionally associated with presumptive glial cells that have migrated from the spinal cord for a short distance. Beyond the vertebral primordia, the spinal nerves are not accompanied by Schwann cells. No compartmentalization of the axons within the lumbo-sacral nerves was visible, whereas Schwann cells did segment the nerve into the fascicles in brachial nerves. The lumbo-sacral plexus develops, and its branches grow into the hindlimb despite the absence of Schwann cells. On day 13.5 of gestation, the lumbo-sacral nerve trunks extend well into the distal calf. They are topographically correctly positioned. Their branches enter the muscle primordia and form contacts with their mesenchymal cells though the cutaneous branches are missing. Generally, the outgrowth of lumbo-sacral nerves is slower than in phenotypically normal littermates, whose nerves reach the foot plate at corresponding stages of development. These results demonstrate that the lumbo-sacral plexus and the topographically correct position of lumbo-sacral nerve trunks develop despite the absence of Schwann cells. Therefore Schwann cells are not necessary for the outgrowth and guidance of axons within the limb.
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