ArticleAmerican journal of human genetics1992
Lipoprotein(a) in women twins: heritability and relationship to apolipoprotein(a) phenotypes.
Article in American journal of human genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetics of Low Density Lipoprotein Subclasses in Hypercholesterolemia
Genetic Epidemiology of Coronary Heart Disease Risk in Women Twins
Who cites it
29 citing papers in PubMed, 116 citations in OpenAlex.
- The effects of colchicine on lipoprotein(a)- and oxidized phospholipid-associated cardiovascular disease risk.European journal of preventive cardiology · 2025Trial
- Lipoprotein(a) and Its Role in Peripheral Arterial Disease: A Narrative Review.Vascular health and risk management · 2025Review
- Consideration and Application of Lipoprotein(a) in the Risk Assessment of Atherosclerotic Cardiovascular Disease Risk in Adults.CJC open · 2024Review
- Digital droplet PCR versus quantitative PCR for lipoprotein (a) kringle IV type 2 repeat polymorphism genetic characterization.Journal of clinical laboratory analysis · 2024Article
- Novel lipid biomarkers and ratios as risk predictors for premature coronary artery disease: A retrospective analysis of 2952 patients.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Concomitant Coronary Artery Disease in Identical Twins: Case Report and Systematic Literature Review.Journal of clinical medicine · 2023Review
- The Ability of Lipoprotein (a) Level to Predict Early Carotid Atherosclerosis Is Impaired in Patients With Advanced Liver Fibrosis Related to Metabolic-Associated Fatty Liver Disease.Clinical and translational gastroenterology · 2022Article
- Lipoprotein(a).Handbook of experimental pharmacology · 2022Article
- Broad clinical manifestations of polygenic risk for coronary artery disease in the Women's Health Initiative.Communications medicine · 2022Article
- Machine Learning Prediction of Biomarkers from SNPs and of Disease Risk from Biomarkers in the UK Biobank.Genes · 2021Article
- Article
- Recent Updates of Lipoprotein(a) and Cardiovascular Disease.Chonnam medical journal · 2021Review
- Molecular, Population, and Clinical Aspects of Lipoprotein(a): A Bridge Too Far?Journal of clinical medicine · 2019Review
- Review
- Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families.Journal of lipid research · 2019Article
- Lp(a): Addressing a Target for Cardiovascular Disease Prevention.Current cardiology reports · 2019Review
- Elevated lipoprotein(a) as a new risk factor of cerebral venous sinus thrombosis: association with fibrin clot properties.Journal of thrombosis and thrombolysis · 2019Article
- Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.Nature communications · 2018Article
- Structure, function, and genetics of lipoprotein (a).Journal of lipid research · 2016Review
- Human Genetics and the Causal Role of Lipoprotein(a) for Various Diseases.Cardiovascular drugs and therapy · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Lp(a) is a unique lipoprotein consisting of an LDL-like particle and a characteristic protein, apo(a). Increased levels of Lp(a) constitute a risk factor for coronary heart disease. Variation in the size of the apo(a) protein is a phenotype controlled by the apo(a) gene on chromosome 6 and is related to Lp(a) plasma levels. Based on 169 MZ and 125 DZ adult female twin pairs, this study's purpose was to estimate the proportion of the variation in Lp(a) levels that is due to genetic influences and to determine the extent to which the apo(a) locus explains this heritability. Lp(a) levels were significantly more similar in MZ twins than in DZ twins: mean co-twin differences were 3.9 +/- 5.7 mg/dl and 16.0 +/- 19.9 mg/dl (P less than .001), respectively. Intraclass correlations were .94 in MZ twins and .32 in DZ twins, resulting in a heritability estimate of .94 (P less than .001). Heritability was then calculated using only co-twins with the same apo(a) phenotype: the heritability estimate decreased to .45 but was still highly significant (P less than .001). Therefore, on the basis of heritability analysis of women twins, Lp(a) levels are almost entirely genetically controlled. Variation at the apo(a) locus contributes to this heritability, although other genetic factors could be involved.
Indexed as
Identifiers
1415225PMC1682765W1579995061What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.