ArticleAmerican journal of human genetics1992
Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.
Article in American journal of human genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Allelic association under map error and recombinational heterogeneity: a tale of two sites.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Association mapping of disease loci, by use of a pooled DNA genomic screen.American journal of human genetics · 1997Article
- Likelihood methods for locating disease genes in nonequilibrium populations.American journal of human genetics · 1995Article
- Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region.American journal of human genetics · 1994Article
- Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.American journal of human genetics · 1994Article
- Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.Journal of medical genetics · 1993Article
- Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.Human genetics · 1993Article
- Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping.American journal of human genetics · 1993Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significant linkage disequilibrium has been found between the Huntington disease (HD) gene and DNA markers located around D4S95 and D4S98. The linkage-disequilibrium studies favor the proximal location of the HD gene, in contrast to the conflicting results of recombination analyses. We have analyzed 45 Dutch HD families with 19 DNA markers and have calculated the strength of linkage disequilibrium. Highly significant linkage disequilibrium has been detected with D4S95, consistent with the studies in other populations. In contrast with most other studies, however, the area of linkage disequilibrium extends from D4S10 proximally to D4S95, covering 1,100 kb. These results confirm that the HD gene most likely maps near D4S95.
Indexed as
Identifiers
1415218PMC1682784W1514859281What OpenQuestion holds
Registered trials
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