ArticleProceedings of the National Academy of Sciences of the United States of America1992
A phorbol ester response element within the human T-cell receptor beta-chain enhancer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 100 citations in OpenAlex.
- Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation.Nucleic acids research · 2016Article
- Coordinated dynamic gene expression changes in the central nucleus of the amygdala during alcohol withdrawal.Alcoholism, clinical and experimental research · 2013Article
- Antigen receptor allelic exclusion: an update and reappraisal.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
- The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus.The Journal of experimental medicine · 2009Article
- Core-binding factors in hematopoiesis and immune function.Oncogene · 2004Review
- The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Molecular and cellular biology · 2003Article
- Review
- Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype.Journal of virology · 2002Article
- Article
- Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.Molecular and cellular biology · 2000Article
- Tandemization of a subregion of the enhancer sequences from SRS 19-6 murine leukemia virus associated with T-lymphoid but not other leukemias.Journal of virology · 1999Article
- Core-binding factor influences the disease specificity of Moloney murine leukemia virus.Journal of virology · 1999Article
- Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation.The EMBO journal · 1998Article
- The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.Molecular and cellular biology · 1998Article
- A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.Molecular and cellular biology · 1997Article
- Stability of AML1 (core) site enhancer mutations in T lymphomas induced by attenuated SL3-3 murine leukemia virus mutants.Journal of virology · 1997Article
- Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2.The Journal of experimental medicine · 1997Article
- Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Transcriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: evidence for cooperativity with c-Myb.Journal of virology · 1996Article
- Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The activity of the T-cell receptor beta-chain gene enhancer is increased by activators of the protein kinase C pathway during T-cell activation. Analysis of mutant enhancer constructs identified two elements, beta E2 and beta E3, conferring phorbol ester inducibility. Multimerized beta E2 acted in isolation as a phorbol ester-responsive element. Both beta E2 and beta E3, which contain a consensus Ets-binding site, were shown to bind directly to the product of the c-ets-1 protooncogene. Both regions also bound a second factor, core-binding factor. Mutation of the beta E2 Ets site abolished the inducibility of the beta E2 multimer. beta E2 and beta E3 Ets site mutations also profoundly affected activity and inducibility of the enhancer. In contrast, enhancer activity but not its inducibility was affected by mutation of the beta E2 core-binding factor site. Cotransfection studies showed that Ets-1 specifically repressed activity of the multimerized beta E2 element and the complete T-cell receptor beta-chain enhancer. These data show that the T-cell receptor beta-chain enhancer responds to protein kinase C-mediated activation signals via a functional domain, composed of two elements, which contains binding sites for Ets transcription factors and which is negatively regulated by Ets-1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.