ArticleProceedings of the National Academy of Sciences of the United States of America1992
Regulation of the yeast DNA replication genes through the Mlu I cell cycle box is dependent on SWI6.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Gcn5 and Rpd3 have a limited role in the regulation of cell cycle transcripts during the G1 and S phases in Saccharomyces cerevisiae.Scientific reports · 2019Article
- Checkpoint kinases regulate a global network of transcription factors in response to DNA damage.Cell reports · 2013Article
- Pph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans.PloS one · 2012Article
- G1/S transcription factor orthologues Swi4p and Swi6p are important but not essential for cell proliferation and influence hyphal development in the fungal pathogen Candida albicans.Eukaryotic cell · 2011Article
- New mutant versions of yeast FACT subunit Spt16 affect cell integrity.Molecular genetics and genomics : MGG · 2009Article
- G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1.Molecular and cellular biology · 2003Article
- Article
- Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae.Genes & development · 2002Article
- Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements.Oncogene · 2002Article
- The yeast pafl-rNA polymerase II complex is required for full expression of a subset of cell cycle-regulated genes.Eukaryotic cell · 2002Article
- A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription.Genetics · 2000Article
- Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1998Review
- Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start".Molecular biology of the cell · 1998Article
- Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2.Molecular biology of the cell · 1996Article
- Transcription of mutS and mutL-homologous genes in Saccharomyces cerevisiae during the cell cycle.Molecular & general genetics : MGG · 1996Article
- Binding to the yeast SwI4,6-dependent cell cycle box, CACGAAA, is cell cycle regulated in vivo.Nucleic acids research · 1996Article
- Cyclins and cyclin-dependent kinases: a biochemical view.The Biochemical journal · 1995Review
- The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase.Molecular and cellular biology · 1995Article
- Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2.Molecular and cellular biology · 1995Article
- Cell cycle-dependent phosphorylation and dephosphorylation of the yeast DNA polymerase alpha-primase B subunit.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In Saccharomyces cerevisiae, at least 17 DNA replication genes are coordinately expressed at the G1/S boundary during the cell cycle. All of these genes have the DNA sequence element ACGCGT in their 5' upstream regulatory regions. This sequence has been shown to be essential for periodic expression of the POL1, CDC9, and TMP1 genes. The cyclin (CLN1 and CLN2) and HO genes are another subset of genes that are expressed with the same timing as the DNA replication genes. Their periodic expression requires the participation of two well-characterized transcriptional activators: the SWI4 and SWI6 gene products. In this study, we present evidence that SWI6 contributes to the regulation of DNA replication genes as well. Surprisingly, a preferential requirement for SWI6 over SWI4 is observed in our studies of ACGCGT-dependent reporter gene expression in vivo. This selectivity has not been observed for the other G1/S genes. Correlating with the in vivo results, protein-DNA complexes formed in vitro on multimeric ACGCGT elements are either abolished or reduced in swi6 delta deletion mutants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.