ArticleProceedings of the National Academy of Sciences of the United States of America1992
Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 270 citations in OpenAlex.
- Article
- Census and evaluation of p53 target genes.Oncogene · 2017Review
- Anti-tumor activity of Eurycoma longifolia root extracts against K-562 cell line: in vitro and in vivo study.PloS one · 2014Article
- p53 and the PWWP domain containing effector proteins in chromatin damage repair.Cell & developmental biology · 2013Article
- hnRNP Q regulates translation of p53 in normal and stress conditions.Cell death and differentiation · 2013Article
- p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.Cell cycle (Georgetown, Tex.) · 2012Article
- Activation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes.Oncogene · 2008Article
- High resolution melting for mutation scanning of TP53 exons 5-8.BMC cancer · 2007Article
- Article
- Colostrinin-driven neurite outgrowth requires p53 activation in PC12 cells.Cellular and molecular neurobiology · 2005Article
- Effects of tachyplesin on the regulation of cell cycle in human hepatocarcinoma SMMC-7721 cells.World journal of gastroenterology · 2003Article
- The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.Molecular and cellular biology · 2002Article
- p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells.Oncogene · 2001Article
- Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Homologous and nonhomologous recombination resulting in deletion: effects of p53 status, microhomology, and repetitive DNA length and orientation.Molecular and cellular biology · 2000Article
- The loss of mdm2 induces p53-mediated apoptosis.Oncogene · 2000Article
- Review
- Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest.Journal of virology · 1999Article
- Human SWI-SNF component BRG1 represses transcription of the c-fos gene.Molecular and cellular biology · 1999Article
- p53 and the CNS: tumors and developmental abnormalities.Molecular neurobiology · 1999Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Conditional expression of wild-type (wt) p53 protein in a glioblastoma tumor cell line has been shown to be growth inhibitory. We have now more precisely localized the position in the cell cycle where growth arrest occurs. We show that growth arrest occurs prior to or near the restriction point in late G1 phase of the cell cycle. The effect of wt p53 protein on the expression of four immediate-early genes (c-FOS, c-JUN, JUN-B, and c-MYC), one delayed-early gene (ornithine decarboxylase), and two late-G1/S-phase genes (B-MYB and DNA polymerase alpha) was also examined. Of this subset of growth response genes, only the expression of B-MYB and DNA polymerase alpha was significantly repressed. The possibility that decreased expression of B-MYB may be an important component of growth arrest mediated by wt p53 protein is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.