ArticleProceedings of the National Academy of Sciences of the United States of America1992
In vitro differentiation of embryonic stem cells into lymphocyte precursors able to generate T and B lymphocytes in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells.Experimental hematology & oncology · 2022Review
- Generation of red blood cells from human embryonic/induced pluripotent stem cells for blood transfusion.International journal of hematology · 2012Review
- Induction of hematopoietic differentiation of mouse embryonic stem cells by an AGM-derived stromal cell line is not further enhanced by overexpression of HOXB4.Stem cells and development · 2010Article
- Differentiation of mesodermal cells from pluripotent stem cells.International journal of hematology · 2010Review
- Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host disease.The Journal of experimental medicine · 2004Article
- Autocrine and paracrine effects of an ES-cell derived, BCR/ABL-transformed hematopoietic cell line that induces leukemia in mice.Oncogene · 2001Article
- Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Hemato-lymphoid in vivo reconstitution potential of subpopulations derived from in vitro differentiated embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- In vitro differentiation of murine embryonic stem cells. New approaches to old problems.The Journal of clinical investigation · 1996Review
- In vitro generation of hematopoietic stem cells from an embryonic stem cell line.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Monolayer culture conditions suitable for primitive erythroid cell differentiation from embryonic stem cells in vitro.Development, growth & differentiation · 1995Article
- In vitro generation of lymphoid precursors from embryonic stem cells.The EMBO journal · 1994Article
- RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic stem cells can be induced in vitro, by coculture with the stromal line RP.0.10 and a mixture of interleukins 3, 6, and 7, to differentiate into T (Joro75+) and B (B-220+) lymphocyte progenitors and other (Thy-1+, PgP-1+, c-kit+, Joro75-, B-220-, F4/80-, Mac-1-) hemopoietic precursors. The progeny of in vitro-induced embryonic stem cells can reconstitute the lymphoid compartments of T- and B-lymphocyte-deficient scid mice and generate mature T and B lymphocytes in sublethally irradiated normal mice. Exogenous cytokines can dramatically alter the developmental fate of embryonic stem cells in culture. The in vitro system described here should facilitate the study of molecular events leading to cell-lineage commitment and to the formation of hemopoietic stem cells and their immediate lymphoid progeny.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.