ArticleProceedings of the National Academy of Sciences of the United States of America1992
Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 180 citations in OpenAlex.
- Trial
- A randomised placebo controlled trial of pegylated interferon alpha in active ulcerative colitis.Gut · 2003Trial
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- Inhibitory receptors of plasmacytoid dendritic cells as possible targets for checkpoint blockade in cancer.Frontiers in immunology · 2024Review
- Low CCL2 and CXCL8 Production and High Prevalence of Allergies in Children with Microcephaly Due to Congenital Zika Syndrome.Viruses · 2023Article
- Interferon-β decreases LPS-induced neutrophil recruitment to cardiac fibroblasts.Frontiers in cell and developmental biology · 2023Article
- Immunoregulatory effects of RGMb in gut inflammation.Frontiers in immunology · 2022Article
- Stroma: the forgotten cells of innate immune memory.Clinical and experimental immunology · 2018Review
- The Protective Role of Type I Interferons in the Gastrointestinal Tract.Frontiers in immunology · 2017Review
- The cytokine-serum amyloid A-chemokine network.Cytokine & growth factor reviews · 2016Review
- Interferon-β inhibits glioma angiogenesis through downregulation of vascular endothelial growth factor and upregulation of interferon inducible protein 10.International journal of oncology · 2014Article
- Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis.PloS one · 2011Article
- The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs.Clinical & experimental metastasis · 2010Review
- Type I interferons inhibit the generation of tumor-associated macrophages.Cancer immunology, immunotherapy : CII · 2010Article
- Article
- IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Association of plasma adiponectin concentrations with chronic lymphocytic leukemia and myeloproliferative diseases.International journal of hematology · 2006Article
- Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells.Gene therapy · 2002Article
- Evidence for the causal role of endogenous interferon-alpha/beta in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms.Clinical & experimental metastasis · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The chemotactic cytokine interleukin 8 (IL-8) is produced upon stimulation by various agents in many cell types, including connective-tissue fibroblasts. Tumor necrosis factor (TNF) and IL-1 are potent inducers of IL-8 expression. Earlier we showed that TNF-induced stimulation of IL-8 mRNA accumulation in human FS-4 fibroblasts was inhibited by interferon beta (IFN-beta) or IFN-gamma. Here we show that this inhibition is not specific for TNF, since IFN-beta also reduced IL-8 mRNA accumulation induced by IL-1 or the double-stranded RNA poly (I-C). Treatment with IFN-beta also decreased TNF-induced IL-8 protein accumulation. Interestingly, the inhibitory effect was much less pronounced when IFN-beta was added greater than or equal to 1 hr before TNF. The inhibitory action of IFN-beta on IL-8 mRNA accumulation was undiminished in the presence of inhibitors of protein synthesis. Nuclear run-on assays demonstrated that IFN-beta caused a marked inhibition of TNF-induced IL-8 gene transcription; the transcriptional activation of several other TNF-induced genes was not inhibited by IFN-beta. The results suggest that the specific inhibition of the transcriptional activation of IL-8 by IFN is due either to a transient inactivation of a factor required for IL-8 transcription or to the activation of a selective inhibitory factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.