ArticleNucleic acids research1992
Adenovirus DNA replication facilitates binding of the MLTF/USF transcription factor to the viral major late promoter within infected cells.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- E1B-55K Is a Phosphorylation-Dependent Transcriptional and Posttranscriptional Regulator of Viral Gene Expression in Human Adenovirus C5 Infection.Journal of virology · 2022Article
- Replication-uncoupled histone deposition during adenovirus DNA replication.Journal of virology · 2012Article
- The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts.Journal of virology · 2011Article
- ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68.Journal of virology · 2009Article
- Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression.Molecular systems biology · 2009Article
- Diminishing adenovirus gene expression and viral replication by promoter replacement.Journal of virology · 1997Article
- Stimulation of the adenovirus major late promoter in vitro by transcription factor USF is enhanced by the adenovirus DNA binding protein.Journal of virology · 1994Article
- Interactions of USF and Ku antigen with a human DNA region containing a replication origin.Nucleic acids research · 1993Article
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Authors and funding
3 authors at 1 institution in 2 countries.
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Abstract
The activity of the adenovirus major late promoter is substantially increased as the infection proceeds from the early to late phase. To gain insight into the regulation of this promoter, we analyzed protein-DNA interactions by in vivo DMS and DNasel footprinting during the course of adenovirus infection. Little or no protein interaction at promoter sequences was detected early (5 hr) after infection but strong interactions at the major late transcription factor (MLTF/USF) binding site and at the TATA box were evident late (12 hr) after infection. Comparison of in vivo and in vitro footprints revealed that the in vivo interaction late after infection results from binding of the cellular transcription factor MLTF/USF. Nuclear extracts prepared from uninfected cells as well as cells harvested at 5 and 12 hr after infection contained similar levels of MLTF/USF footprint activity, therefore the lack of a detectable interaction early after infection is not due to reduced levels of the factor early in the viral growth cycle. Viral DNA replication was required for MLTF/USF binding at the major late promoter. These results indicate that DNA replication participates in the regulation of adenovirus late gene expression by facilitating the binding of a transcription factor to the major late promoter.
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