ArticleNucleic acids research1992
Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options.Molecular cancer · 2026Review
- Understanding the significance of biological clock and its impact on cancer incidence.Cancer letters · 2022Review
- Review
- Mutations of Chromatin Structure Regulating Genes in Human Malignancies.Current protein & peptide science · 2016Review
- The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele.Cell death and differentiation · 2014Article
- The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress.Molecular cell · 2012Article
- Article
- The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.Molecular biology of the cell · 2011Article
- The nucleosome remodeling factor.FEBS letters · 2011Review
- Characterization of novel isoforms and evaluation of SNF2L/SMARCA1 as a candidate gene for X-linked mental retardation in 12 families linked to Xq25-26.BMC medical genetics · 2008Article
- DNA sequence- and conformation-directed positioning of nucleosomes by chromatin-remodeling complexes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Topography of the ISW2-nucleosome complex: insights into nucleosome spacing and chromatin remodeling.The EMBO journal · 2004Article
- Isolation of human NURF: a regulator of Engrailed gene expression.The EMBO journal · 2003Article
- Yeast Isw1p forms two separable complexes in vivo.Molecular and cellular biology · 2003Article
- WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.The EMBO journal · 2002Article
- HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.The EMBO journal · 2000Article
- ATP-dependent chromatin-remodeling complexes.Molecular and cellular biology · 2000Review
- A family of chromatin remodeling factors related to Williams syndrome transcription factor.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Direct interaction between Rsc6 and Rsc8/Swh3,two proteins that are conserved in SWI/SNF-related complexes.Nucleic acids research · 1998Article
- SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells.Molecular and cellular biology · 1997Article
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9 authors.
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Abstract
We performed positional cloning of genes carried on yeast artificial chromosomes that span a human translocation breakpoint associated with a human disease and isolated by chance human and bovine genes with strong homology to the S. cerevisiae genes, SNF2/SWI2 and STH1, and the D. melanogaster gene brahma. We report here sequence analysis, expression data, and functional studies for this human SNF2-like gene (hSNF2L) and its bovine homolog (bovSNF2L). Despite strong homology at the amino acid level, hSNF2L is not capable of complementing the yeast mutations snf2 or sth1 in S. cerevisiae. Furthermore, in contrast to SNF2 itself, a fusion protein consisting of the DNA binding domain of LexA and hSNF2L did not transactivate a reporter gene downstream of LexA binding sites in a yeast expression system. The strong similarity between hSNF2L and these yeast and drosophila genes suggest that the mammalian genes are part of an evolutionarily conserved family that has been implicated as global activators of transcription in yeast and fruitflies but whose function in mammals remains unknown.
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