ArticleNucleic acids research1992
Spontaneous chromosome rearrangements in the protozoan Giardia lamblia: estimation of mutation rates.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Constitutive aneuploidy and genomic instability in the single-celled eukaryote Giardia intestinalis.MicrobiologyOpen · 2016Article
- Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates.BMC genomics · 2015Article
- Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate.BMC genomics · 2010Article
- Biology of Giardia lamblia.Clinical microbiology reviews · 2001Review
- Artificial linear mini-chromosomes for Trypanosoma brucei.Nucleic acids research · 1996Article
- Structure of a frequently rearranged rRNA-encoding chromosome in Giardia lamblia.Nucleic acids research · 1995Article
- Physical map of a 2 Mb chromosome of the intestinal protozoan parasite Giardia duodenalis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1994Article
- Allele-specific expression of a variant-specific surface protein (VSP) of Giardia lamblia.Nucleic acids research · 1994Article
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Authors and funding
3 authors.
Funding
Abstract
Subcloned lines of the WB strain of Giardia lamblia contain polymorphic ribosomal RNA (rRNA) encoding chromosomes (Le Blancq et al., Nucl. Acids Res. 1991, 19, 4405-4412). We show that in a continuously propagated culture of G.lamblia trophozoites the proportion of trophozoites with rearranged rRNA encoding chromosomes gradually increases, consistent with the high mutation rate of about 1% per cell per division cycle. This conclusion is based on the finding in one experiment that after about 8 division cycles 20% of the population consisted of independent mutants, while after approximately 100 division cycles 87.5% of the population were independent mutants. In a second experiment, approximately 38% and 71.5% of the trophozoites were independent mutants after approximately 9 and approximately 100 division cycles, respectively. The data show that the genome of the WB strain of G.lamblia has a highly recombinogenic phenotype. Extensive karyotype heterogeneity has also been observed among recently isolated G.lamblia strains obtained from a defined geographic area (Korman et al., J. Clin. Invest. 1992, 89, 1725-1733) suggesting that a high mutation rate might also occur in vivo.
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