ArticleMolecular and cellular biology1992
Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Measurement of histone replacement dynamics with genetically encoded exchange timers in yeast.Nature biotechnology · 2021Article
- H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect.Current biology : CB · 2020Article
- DNA damage response activates respiration and thereby enlarges dNTP pools to promote cell survival in budding yeast.The Journal of biological chemistry · 2019Article
- A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A.Genetics · 2018Article
- Uncoupling histone turnover from transcription-associated histone H3 modifications.Nucleic acids research · 2015Article
- Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Regulation of histone gene transcription in yeast.Cellular and molecular life sciences : CMLS · 2014Review
- Conserved regulators of nucleolar size revealed by global phenotypic analyses.Science signaling · 2013Article
- WEE1 tyrosine kinase, a novel epigenetic modifier.Trends in genetics : TIG · 2013Review
- Nucleosome assembly factors CAF-1 and HIR modulate epigenetic switching frequencies in an H3K56 acetylation-associated manner in Candida albicans.Eukaryotic cell · 2013Article
- Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2013Article
- Direct interplay among histones, histone chaperones, and a chromatin boundary protein in the control of histone gene expression.Molecular and cellular biology · 2012Article
- The great unravelling: chromatin as a modulator of the aging process.Trends in biochemical sciences · 2012Review
- H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes.Nature structural & molecular biology · 2012Article
- Regulation of histone gene expression in budding yeast.Genetics · 2012Review
- Chromatin and transcription in yeast.Genetics · 2012Review
- The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.Biochimica et biophysica acta · 2012Article
- Direct regulation of nucleosome density by the conserved AAA-ATPase Yta7.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.Molecular and cellular biology · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Histone mRNA synthesis is tightly regulated to S phase of the yeast Saccharomyces cerevisiae cell cycle as a result of transcriptional and posttranscriptional controls. Moreover, histone gene transcription decreases rapidly if DNA replication is inhibited by hydroxyurea or if cells are arrested in G1 by the mating pheromone alpha-factor. To identify the transcriptional controls responsible for cycle-specific histone mRNA synthesis, we have developed a selection for mutations which disrupt this process. Using this approach, we have isolated five mutants (hpc1, hpc2, hpc3, hpc4, and hpc5) in which cell cycle regulation of histone gene transcription is altered. All of these mutations are recessive and belong to separate complementation groups. Of these, only one (hpc1) falls in one of the three complementation groups identified previously by other means (M. A. Osley and D. Lycan, Mol. Cell. Biol. 7:4204-4210, 1987), indicating that at least seven different genes are involved in the cell cycle-specific regulation of histone gene transcription. hpc4 is unique in that derepression occurs only in the presence of hydroxyurea but not alpha-factor, suggesting that at least one of the regulatory factors is specific to histone gene transcription after DNA replication is blocked. One of the hpc mutations (hpc2) suppresses delta insertion mutations in the HIS4 and LYS2 loci. This effect allowed the cloning and sequence analysis of HPC2, which encodes a 67.5-kDa, highly charged basic protein.
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