ArticleMolecular and cellular biology1992
The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 102 citations in OpenAlex.
- The phenotypic characterization of mouse floxedRegenerative therapy · 2025Article
- Association Between Simian Virus 40 and Human Tumors.Frontiers in oncology · 2019Review
- Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.Journal of cellular physiology · 2015Article
- Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors.TheScientificWorldJournal · 2012Article
- Development and characterization of a mouse floxed Bmp2 osteoblast cell line that retains osteoblast genotype and phenotype.Cell and tissue research · 2011Article
- IGF-IR-dependent expression of Survivin is required for T-antigen-mediated protection from apoptosis and proliferation of neural progenitors.Cell death and differentiation · 2010Article
- IGF-IR in neuroprotection and brain tumors.Frontiers in bioscience (Landmark edition) · 2009Review
- Simian virus 40 in humans.Infectious agents and cancer · 2007Article
- Adeno-associated viral-mediated insulin-like growth factor delivery protects motor neurons in vitro.Neuromolecular medicine · 2004Article
- Simian virus 40 infection of humans.Journal of virology · 2003Article
- Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts.Molecular and cellular biology · 2002Article
- Review
- Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.Journal of virology · 1999Article
- Identification in human brain tumors of DNA sequences specific for SV40 large T antigen.Brain pathology (Zurich, Switzerland) · 1999Article
- Effects of epidermal growth factor on growth of cell lines established from cynomolgus monkey hepatocytes with SV40 T antigen.In vitro cellular & developmental biology. Animal · 1997Article
- Mechanisms of transcriptional regulation of cellular genes by SV40 large T- and small T-antigens.Virus genes · 1997Review
- Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.Journal of virology · 1996Article
- G-protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells.The Journal of clinical investigation · 1996Article
- Cytokines in tumour growth, migration and metastasis.World journal of urology · 1996Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We have used a plasmid expressing a temperature-sensitive (ts) mutant of simian virus 40 (SV40) T antigen, stably transfected into 3T3 cells, to study the role of insulinlike growth factor 1 (IGF-1) and its receptor in T-antigen-mediated growth. While 3T3 cells do not grow in serum-free medium, in 1% serum, or with the sole addition of either platelet-derived growth factor (PDGF) or IGF-1, cells expressing the tsA T antigen (BALB 58 cells) grow at 34 degrees C in either PDGF or 1% serum but not in IGF-1. At the restrictive temperature (39.6 degrees C), these cells can only grow in 10% serum. We show that BALB 58 cells, at 34 degrees C, have a markedly increased expression of IGF-1 and IGF-1 mRNA and that their growth in 1% serum (at 34 degrees C) is inhibited by an antisense oligodeoxynucleotide to the IGF-1 receptor RNA. When this tsA plasmid is stably transfected into cells constitutively overexpressing the human IGF-1 receptor cDNA, the resulting cell lines show a constitutively phosphorylated IGF-1 receptor and grow in serum-free medium at 34 degrees C (but not at 39.6 degrees C). A functional SV40 T antigen also increases the expression of a plasmid in which the reporter luciferase gene is under the control of a rat IGF-1 promoter. We conclude (i) that the SV40 T antigen induces the expression of IGF-1 and IGF-1 mRNA, at least in part by a transcriptional mechanism, thus altering the growth factors requirements, and (ii) that, in BALB/c3t3 cells, the SV40 T antigen necessitates a functional IGF-1 receptor for its growth-stimulating effect in low serum (or PDGF).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.