ArticleMolecular and cellular biology1992
A transcriptionally active form of GAL4 is phosphorylated and associated with GAL80.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Interplay of a ligand sensor and an enzyme in controlling expression of the Saccharomyces cerevisiae GAL genes.Eukaryotic cell · 2012Article
- Review
- Rapid GAL gene switch of Saccharomyces cerevisiae depends on nuclear Gal3, not nucleocytoplasmic trafficking of Gal3 and Gal80.Genetics · 2011Article
- Localization and interaction of the proteins constituting the GAL genetic switch in Saccharomyces cerevisiae.Eukaryotic cell · 2008Article
- Phosphorylation of the Gal4 DNA-binding domain is essential for activator mono-ubiquitylation and efficient promoter occupancy.Molecular bioSystems · 2008Article
- Gal80 dimerization and the yeast GAL gene switch.Genetics · 2005Article
- The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.Genes & development · 2001Article
- Multiple signals regulate GAL transcription in yeast.Molecular and cellular biology · 2000Article
- The regulator of the yeast proline utilization pathway is differentially phosphorylated in response to the quality of the nitrogen source.Molecular and cellular biology · 2000Article
- A new class of repression modules is critical for heme regulation of the yeast transcriptional activator Hap1.Molecular and cellular biology · 1999Article
- Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus laevis embryos, is independent of histone deacetylase.Molecular and cellular biology · 1999Article
- Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4p-activated genes in Saccharomyces cerevisiae.Molecular and cellular biology · 1997Article
- The DNA binding and activation domains of Gal4p are sufficient for conveying its regulatory signals.Molecular and cellular biology · 1997Article
- Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Phosphorylation of Ga14p at a single C-terminal residue is necessary for galactose-inducible transcription.Molecular and cellular biology · 1996Article
- Interaction of Saccharomyces cerevisiae Pho2 with Pho4 increases the accessibility of the activation domain of Pho4.Molecular & general genetics : MGG · 1996Article
- TBP mutants defective in activated transcription in vivo.The EMBO journal · 1995Article
- Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Shared control of maltose induction and catabolite repression of the MAL structural genes in Saccharomyces.Molecular & general genetics : MGG · 1994Article
- Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiae.Molecular and cellular biology · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The GAL4 activator and GAL80 repressor proteins regulate the expression of yeast genes in response to galactose. A complex of the two proteins isolated from glucose-grown cells is inactive in an in vitro transcription reaction but binds DNA and blocks activation by the GAL4-VP16 chimeric activator. The complex purified from galactose-grown cells contains a mixture of phosphorylated and unphosphorylated forms of GAL4. The galactose-induced form of GAL4 activates in vitro transcription to levels similar to those seen with GAL4-VP16. The induced GAL4 complex is indistinguishable in size and apparent shape from the uninduced complex, consistent with a continued association with GAL80. These results confirm in vivo analyses that correlate GAL4 phosphorylation with galactose induction and support a model of transcriptional activation that does not require GAL80 dissociation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.