ArticleMolecular and cellular biology1992
Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 106 citations in OpenAlex.
- Article
- Modeling cutaneous squamous carcinoma development in the mouse.Cold Spring Harbor perspectives in medicine · 2014Review
- Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.The Journal of investigative dermatology · 2013Article
- Epithelial stem cells, wound healing and cancer.Nature reviews. Cancer · 2012Review
- Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis.Molecular carcinogenesis · 2011Review
- Dual inhibition of both the epidermal growth factor receptor and erbB2 effectively inhibits the promotion of skin tumors during two-stage carcinogenesis.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Molecular mechanisms of mouse skin tumor promotion.Cancers · 2010Article
- RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factor.The American journal of pathology · 2009Article
- Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells.Breast cancer research and treatment · 2008Article
- Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology.The American journal of pathology · 2008Review
- Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.Toxicology and applied pharmacology · 2007Article
- Transgenic models of pancreatic cancer.International journal of gastrointestinal cancer · 2003Review
- MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.The EMBO journal · 2000Article
- Article
- Immunohistochemical localization of heparin-binding epidermal growth factor-like growth factor in normal skin and skin cancers.The Histochemical journal · 1997Article
- Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice.The American journal of pathology · 1996Article
- Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis.Molecular and cellular biology · 1995Article
- Transgenic mice and squamous multistage skin carcinogenesis.Cancer metastasis reviews · 1995Review
- Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice.Journal of virology · 1994Article
- 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The induction of skin papillomas in mice can be divided into two different stages. Chemical initiation frequently elicits mutations in the Ha-ras gene, leading to the constitutive activation of ras. The second step, promotion, involves repetitive topical application of phorbol esters or wounding, leading to epidermal hyperproliferation and papilloma formation. We have found that overexpression of transforming growth factor alpha (TGF-alpha) in the basal epidermal layer of transgenic mice yielded papillomas directly upon wounding or 12-O-tetradecanoylphorbol-13-acetate treatment without the need for an initiator. Moreover, papillomas from TGF-alpha mice did not exhibit mutations in the Ha-ras gene. Interestingly, TGF-alpha acted synergistically with 12-O-tetradecanoylphorbol-13-acetate to enhance epidermal hyperproliferation. Our results demonstrate a central role for TGF-alpha overexpression in tumorigenesis and provide an important animal model for the study of skin tumorigenesis.
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