ArticleMolecular and cellular biology1992
Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Selective Activation of AlternativeGenes · 2018Article
- Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.American journal of human genetics · 2014Article
- Glucocorticoid resistance in a multiple myeloma cell line is regulated by a transcription elongation block in the glucocorticoid receptor gene (NR3C1).British journal of haematology · 2009Article
- TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.Oncogene · 2008Article
- In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development.Genes, chromosomes & cancer · 2007Article
- The c-myc insulator element and matrix attachment regions define the c-myc chromosomal domain.Molecular and cellular biology · 2003Article
- Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation.The Biochemical journal · 2001Article
- Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner.Molecular and cellular biology · 1999Article
- Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts.Molecular and cellular biology · 1997Article
- TFIIH functions in regulating transcriptional elongation by RNA polymerase II in Xenopus oocytes.Molecular and cellular biology · 1996Article
- The effect of cyclic-AMP on the regulation of c-myc expression in T lymphoma cells.The Journal of clinical investigation · 1995Article
- Regulatory elements in the immunoglobulin kappa locus induce c-myc activation and the promoter shift in Burkitt's lymphoma cells.The EMBO journal · 1993Article
- Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters.Molecular and cellular biology · 1993Article
- Distinct properties of c-myc transcriptional elongation are revealed in Xenopus oocytes and mammalian cells and by template titration, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and promoter mutagenesis.Molecular and cellular biology · 1993Article
- Regulation of eukaryotic gene expression by transcriptional attenuation.Molecular biology of the cell · 1993Review
- Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase II promoters.The EMBO journal · 1993Article
- Transcription elongation in the human c-myc gene is governed by overall transcription initiation levels in Xenopus oocytes.Molecular and cellular biology · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A conditional block to transcription elongation provides one mechanism for controlling the steady-state levels of c-myc RNA in mammalian cells. Although prematurely terminated c-myc RNAs are not detectable in mammalian cells, truncated c-myc RNAs with 3' ends that map near the end of the first exon are transcribed from human c-myc templates injected into Xenopus oocytes germinal vesicles. A series of linker scanner and deletion mutants within the c-myc P2 promoter was tested in the Xenopus oocyte injection assay to determine the potential contribution of promoter elements to the elongation or premature termination of c-myc transcription. Although this analysis failed to identify sequences in the P2 promoter that significantly affect the elongation or termination of P2-initiated transcripts, our results suggest that sequences within the P2 promoter contribute to the premature termination of transcripts initiated at the upstream P1 promoter. A subset of these sequences is essential for the efficient elongation of P1-initiated transcripts through intrinsic sites of termination at the end of exon 1. These sequences affect P1 elongation when they are downstream of the site of initiation, and we hypothesize that they may be analogous to a class of prokaryotic elements required for antitermination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.