ArticleMolecular and cellular biology1992
Histone H2B gene transcription during Xenopus early development requires functional cooperation between proteins bound to the CCAAT and octamer motifs.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- De novo transcriptome assembly from the gonads of a scleractinian coral, Euphyllia ancora: molecular mechanisms underlying scleractinian gametogenesis.BMC genomics · 2020Article
- The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease.The Yale journal of biology and medicine · 2016Review
- Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells.Cellular & molecular immunology · 2010Article
- The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites.Oncogene · 2008Article
- Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage.Oncogene · 2001Article
- Translation of maternal TATA-binding protein mRNA potentiates basal but not activated transcription in Xenopus embryos at the midblastula transition.Molecular and cellular biology · 1999Article
- Regulation of the Dlx3 homeobox gene upon differentiation of mouse keratinocytes.The Journal of biological chemistry · 1999Article
- The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes.Molecular biology reports · 1998Article
- POU domain transcription factors in embryonic development.Molecular biology reports · 1997Review
- CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes.Molecular and cellular biology · 1996Article
- The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation.The EMBO journal · 1996Article
- Stimulation of basal transcription from the mouse mammary tumor virus promoter by Oct proteins.Journal of virology · 1995Article
- Interaction of the CCAAT displacement protein with shared regulatory elements required for transcription of paired histone genes.Molecular and cellular biology · 1995Article
- Molecular basis of the activation of basal histone H1(0) gene expression.Nucleic acids research · 1994Article
- The promoter of the Xwnt-5C gene contains octamer and AP-2 motifs functional in Xenopus embryos.Nucleic acids research · 1994Article
- Mutually exclusive binding of two cellular factors within a critical promoter region of the gene for the IE110k protein of herpes simplex virus.Journal of virology · 1993Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The ubiquitously expressed transcription factor Oct-1 and several other members of the POU domain protein family bind to a site, termed the octamer motif, that functions in the promoter and enhancer regions of a variety of genes expressed under diverse conditions. An octamer motif present in a conserved histone H2B-specific promoter element is required for S-phase-specific transcription of mammalian histone H2B genes in cultured cells. We have previously shown that the octamer motif in a Xenopus histone H2B gene promoter was inactive in nondividing frog oocytes. Here we show that the octamer motif, in addition to regulatory elements (TATAA, CCAAT, and ATF motifs) that are active in oocytes, is required for maximal H2B gene transcription in developing frog embryos. Factors binding to each of the H2B upstream promoter elements are present in oocytes and increase slightly in abundance during early development. The activity of the H2B octamer motif in embryos is not specifically associated with increased binding by Oct-1 or the appearance of novel octamer-binding proteins but requires the presence of an intact CCAAT motif. Our results indicate that synergistic interactions among promoter-bound factors are important for octamer-dependent H2B transcription. We suggest that the activity of the H2B promoter is regulated primarily by changes in the interactions between proteins already bound to the promoter rather than by alterations in their intrinsic abilities to bind DNA.
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