ArticleMolecular and cellular biology1992
Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 73 citations in OpenAlex.
- Oncolytic Adenovirus Armed with a Novel Agonist of the CD137 Immune Checkpoint Stimulator Suppresses Tumor Growth.Vaccines · 2024Article
- Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus.Nature communications · 2022Article
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- Adenovirus type 5 early region 1B 156R protein promotes cell transformation independently of repression of p53-stimulated transcription.Journal of virology · 2007Article
- The steroid receptor co-activator-1 (SRC-1) potentiates TGF-beta/Smad signaling: role of p300/CBP.Oncogene · 2005Article
- Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function.Nucleic acids research · 2003Article
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- TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.Molecular biology of the cell · 1998Article
- A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.Molecular and cellular biology · 1998Article
- The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.Genes & development · 1998Article
- AR1 is an integral part of the adenovirus type 2 E1A-CR3 transactivation domain.Journal of virology · 1998Article
- E1A represses apolipoprotein AI enhancer activity in liver cells through a pRb- and CBP-independent pathway.Nucleic acids research · 1998Article
- CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Adenovirus mediated-gene transfer into cardiomyocytes.Molecular and cellular biochemistry · 1997Article
- The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.Molecular and cellular biology · 1997Article
- The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.Molecular and cellular biology · 1997Article
- The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation.Nucleic acids research · 1996Article
- E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies have shown that the adenovirus E1A12S product can trans-activate transcription by activating the transcription factor E2F. However, E2F cannot be the only target for the E1A12S product, since several cellular promoters have been found to be activated by the E1A12S protein even though they lack E2F sites. Indeed, we now show that activation of the hsp70 promoter by the E1A12S product requires the TATAA sequence. Moreover, activation of the hsp70 promoter requires the N-terminal domain of the E1A protein and does not require the conserved region 2 sequences which are required for the E2F-dependent activation of transcription. We conclude that the targeting of distinct transcription factors, leading to trans-activation of transcription of multiple promoters, involves distinct domains of the E1A proteins that are also required for oncogenic activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.