ArticleThe Journal of experimental medicine1992
Activin A/erythroid differentiation factor is induced during human monocyte activation.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Periodontitis induces skeletal muscle atrophy by increasing circulating levels of activin A.Nature communications · 2026Article
- INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling.Acta pharmacologica Sinica · 2025Article
- Article
- Neutrophil-derived Activin-A moderates their pro-NETotic activity and attenuates collateral tissue damage caused by Influenza A virus infection.Frontiers in immunology · 2024Article
- Different Immunoregulation Roles of Activin A Compared With TGF-β.Frontiers in immunology · 2022Review
- Role of Activins in Hepcidin Regulation during Malaria.Infection and immunity · 2017Article
- Immunoregulation by members of the TGFβ superfamily.Nature reviews. Immunology · 2016Review
- Activin A programs the differentiation of human TFH cells.Nature immunology · 2016Article
- Activin, neutrophils, and inflammation: just coincidence?Seminars in immunopathology · 2013Review
- Cytokine gene expression profile in monocytic cells after a co-culture with epithelial cells.Immunologic research · 2012Article
- The biology of activin: recent advances in structure, regulation and function.The Journal of endocrinology · 2009Review
- The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation.Reproductive biology and endocrinology : RB&E · 2008Article
- Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Activin induces tactile allodynia and increases calcitonin gene-related peptide after peripheral inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Expression profiling of cardiovascular disease.Human genomics · 2004Review
- The promotion of plasmacytoma tumor growth by mesenchymal stroma is antagonized by basic fibroblast growth factor induced activin A.Leukemia · 2001Article
- cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection.Infection and immunity · 2001Article
- Induced expression of the new cytokine, activin A, in human monocytes: inhibition by glucocorticoids and retinoic acid.Immunology · 1996Article
- Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis.The American journal of pathology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activin A/erythroid differentiation factor (EDF), a dimeric polypeptide hormone composed of two beta A subunits, regulates growth and erythroid differentiation of human hematopoietic progenitor and erythroleukemia cells. We have identified activated human peripheral blood monocytes as a natural source of activin A/EDF. In these cells, lipopolysaccharide (LPS) induced rapidly the expression of the beta A subunit mRNAs through protein kinase C-dependent transcriptional regulation. The beta A subunit mRNA expression was also increased by 1,25-dihydroxyvitamin D3, an inducer of macrophage maturation of monocytes. Western analysis with an anti-beta A antibody and an erythroid differentiation bioassay confirmed that the conditioned media of LPS-activated monocytes contained the activin A/EDF protein. We suggest that monocyte/macrophage-derived activin A/EDF may not only modulate hematopoiesis but may also act as a mediator molecule in the diverse physiologic and pathogenetic events in which these cells are involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.