ArticleThe Journal of experimental medicine1992
Differential structure-function requirements of the transmembranal domain of the B cell antigen receptor.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Structural Model of the mIgM B-Cell Receptor Transmembrane Domain From Self-Association Molecular Dynamics Simulations.Frontiers in immunology · 2018Article
- Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction.The EMBO journal · 1997Article
- Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes.The Journal of experimental medicine · 1995Article
- Ig alpha and Ig beta are functionally homologous to the signaling proteins of the T-cell receptor.Molecular and cellular biology · 1994Article
- The B cell antigen receptor complex: mechanisms and implications of tyrosine kinase activation.Immunologic research · 1994Review
- Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.The Journal of experimental medicine · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By generating phosphorylcholine (PC)-specific, wild-type (mu), and chimeric (mu-I-A alpha) antigen receptor transfectants of mature B cells, we have shown that the COOH terminus of the mu heavy chain is essential for three major functions: immediate signal transduction (measured as changes in intracellular Ca2+), antigen presentation, and induction of immunoglobulin M secretion. A more detailed analysis of structural requirements of the COOH-terminal domains contributing to these functions was achieved by systematically replacing the spacer, cytoplasmic, and transmembranal domains of the mu-I-A alpha chimeric chain with those of mu. Using this rescue approach, we show that the carboxyl two-thirds of the transmembranal domain (proximal to the cytoplasmic domain) is required for induction of intracellular Ca2+, whereas the complete transmembranal domain is required for the function of antigen presentation but is dispensable for induction of antibody secretion.
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